May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Does Retinal Arteriolar Narrowing Precede the Long-Term Development of Open-Angle Glaucoma: Blue Mountains Eye Study Findings
Author Affiliations & Notes
  • B. Taylor
    Ophthalmology (Centre for Vision Research, Westmead Millennium Institute, Westmead Hospital), University of Sydney, Sydney, Australia
  • J. Wang
    Ophthalmology (Centre for Vision Research, Westmead Millennium Institute, Westmead Hospital), University of Sydney, Sydney, Australia
  • E. Rochtchina
    Ophthalmology (Centre for Vision Research, Westmead Millennium Institute, Westmead Hospital), University of Sydney, Sydney, Australia
  • P. Mitchell
    Ophthalmology (Centre for Vision Research, Westmead Millennium Institute, Westmead Hospital), University of Sydney, Sydney, Australia
  • Blue Mountains Eye Study
    Ophthalmology (Centre for Vision Research, Westmead Millennium Institute, Westmead Hospital), University of Sydney, Sydney, Australia
  • Footnotes
    Commercial Relationships B. Taylor, None; J. Wang, None; E. Rochtchina, None; P. Mitchell, None.
  • Footnotes
    Support NHMRC project grants 974159 and 211069
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 3085. doi:https://doi.org/
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      B. Taylor, J. Wang, E. Rochtchina, P. Mitchell, Blue Mountains Eye Study; Does Retinal Arteriolar Narrowing Precede the Long-Term Development of Open-Angle Glaucoma: Blue Mountains Eye Study Findings. Invest. Ophthalmol. Vis. Sci. 2007;48(13):3085. doi: https://doi.org/.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose:: To assess whether baseline retinal arteriolar narrowing predicts incident open angle glaucoma in an older population.

Methods:: The Blue Mountains Eye Study (BMES) examined 3,654 participants aged 49+ years at baseline (1992-4). Retinal photographs were digitised and retinal arteriolar and venular diameters measured. Open angle glaucoma (OAG) was diagnosed from matching visual field defects and optic disc cupping, without reference to intra-ocular pressure (IOP) level. Associations between incident OAG and arteriolar or venular diameter were assessed after adjusting for baseline age, gender, IOP, use of glaucoma medications, vertical disc diameter, cup-to-disc ratio and baseline disc haemorrhage. Vessel diameter was analysed continuously and by tertile.

Results:: After excluding subjects with glaucoma or optic disc abnormalities at baseline or those with incomplete data, 2328 participants seen at the 5- and/or 10-year visits were considered at risk of incident OAG. This developed in 99 eyes of 78 participants (3.4%), at either the 5- or 10-year follow-up exam. After adjusting for age and sex, narrower baseline arteriolar and venular diameter was associated with an increased risk of incident OAG (narrowest vs widest tertile, odds ratio, OR 2.32, 95% confidence interval, CI, 1.28- 4.20, p for trend 0.004 for arterioles and OR 1.76, CI 1.01- 3.05, p for trend 0.04 for venules). Each standard deviation (SD) decrease in vessel diameter was associated with an increased risk of incident OAG (OR 1.36 CI 1.07- 1.73 for arterioles and OR 1.28 CI 1.07- 1.73 for venules). After further adjusting for IOP, use of glaucoma medications, vertical disc diameter, cup-to-disc ratio and baseline disc haemorrhage, the associations with arteriolar narrowing remained but became borderline non-significant (OR 1.86, CI 1.00- 3.61, p for trend 0.057 for the lowest vs highest tertile, and OR 1.24, CI 0.94- 1.65 per SD decrease). The association with narrowed venular diameter was no longer present.

Conclusions:: These findings suggest that retinal arteriolar narrowing may precede the development of OAG. This adds to previously reported BMES data which demonstrated a strong cross-sectional association between OAG and retinal arteriolar narrowing.

Keywords: clinical (human) or epidemiologic studies: prevalence/incidence 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×