May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Retinal Vascular Caliber and the 5-Year Cumulative Prevalence of Retinopathy Lesions in an Australian Population: The AusDiab Study
S. L. Rogers; G. Tikellis; C. A. Harper; J. Shaw; P. Z. Zimmet; P. Mitchell; H. R. Taylor; J. J. Wang; T. Y. Wong
Author Affiliations & Notes
  • S. L. Rogers
    Retinal Vascular Imaging Centre, Centre for Eye Research Australia, East Melbourne, Australia
  • G. Tikellis
    Retinal Vascular Imaging Centre, Centre for Eye Research Australia, East Melbourne, Australia
  • C. A. Harper
    The Royal Victorian Eye and Ear Hospital, East Melbourne, Australia
  • J. Shaw
    The International Diabetes Institute, Caulfield, Australia
  • P. Z. Zimmet
    The International Diabetes Institute, Caulfield, Australia
  • P. Mitchell
    Centre for Vision Research, Department of Ophthalmology, University of Sydney, Australia
  • H. R. Taylor
    Retinal Vascular Imaging Centre, Centre for Eye Research Australia, East Melbourne, Australia
  • J. J. Wang
    Retinal Vascular Imaging Centre, Centre for Eye Research Australia, East Melbourne, Australia
    Centre for Vision Research, Department of Ophthalmology, University of Sydney, Australia
  • T. Y. Wong
    Retinal Vascular Imaging Centre, Centre for Eye Research Australia, East Melbourne, Australia
  • Footnotes
    Commercial Relationships S.L. Rogers, None; G. Tikellis, None; C.A. Harper, None; J. Shaw, None; P.Z. Zimmet, None; P. Mitchell, None; H.R. Taylor, None; J.J. Wang, None; T.Y. Wong, None.
  • Footnotes
    Support NHMRC Grants 350448 and 233200; Charles Viertel Charitable Foundation Grant
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 3086. doi:
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      S. L. Rogers, G. Tikellis, C. A. Harper, J. Shaw, P. Z. Zimmet, P. Mitchell, H. R. Taylor, J. J. Wang, T. Y. Wong; Retinal Vascular Caliber and the 5-Year Cumulative Prevalence of Retinopathy Lesions in an Australian Population: The AusDiab Study. Invest. Ophthalmol. Vis. Sci. 2007;48(13):3086.

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Abstract

Purpose:: To describe the association of retinal vessel caliber with the 5-year cumulative prevalence of retinopathy lesions in people with and without diabetes or abnormal glucose metabolism.

Methods:: As part of the AusDiab study, retinal photography was taken at baseline and after five years in 1,022 individuals aged 25 years and older. Retinal vessel caliber was measured from baseline photographs using a computer-based method. Retinopathy lesions detected at baseline and after five years were confirmed using side-by-side grading. Logistic regression was used to calculate the odds ratios (OR) of the 5-year cumulative prevalence of retinopathy lesions associated with baseline retinal vessel caliber, adjusting for age, gender, glycosylated hemoglobin, glucose metabolism status (normal, impaired fasting glucose [IFG] or impaired glucose tolerance [IGT], diabetes), systolic blood pressure, body mass index, total cholesterol and smoking.

Results:: Overall, the 5-year cumulative prevalence of retinopathy lesions was 8.2%. Among individuals with normal, IFG/IGT, and diabetes, the cumulative prevalence rates were 6.3%, 4.2%, and 16.4%, respectively. Larger retinal arteriolar caliber was associated with an increased likelihood of having retinopathy lesions (OR=1.4, 95% confidence intervals [CI] 0.7-2.6 for the middle, and OR=2.3, CI 1.1-4.5 for the widest compared to narrowest arteriolar caliber tertile). Retinal venular caliber was not associated with the prevalence of retinopathy lesions (OR=1.2, CI 0.6-2.2 for the middle and OR=1.1, CI 0.5-2.2 for the widest compared to narrowest venular caliber tertile).

Conclusions:: Wider retinal arteriolar caliber was related to 5-year cumulative prevalence of isolated retinopathy lesions, independent of other risk factors.

Keywords: diabetic retinopathy • clinical (human) or epidemiologic studies: prevalence/incidence • clinical (human) or epidemiologic studies: risk factor assessment 
© 2007, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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