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S. L. Rogers, G. Tikellis, C. A. Harper, J. Shaw, P. Z. Zimmet, P. Mitchell, H. R. Taylor, J. J. Wang, T. Y. Wong; Retinal Vascular Caliber and the 5-Year Cumulative Prevalence of Retinopathy Lesions in an Australian Population: The AusDiab Study. Invest. Ophthalmol. Vis. Sci. 2007;48(13):3086.
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To describe the association of retinal vessel caliber with the 5-year cumulative prevalence of retinopathy lesions in people with and without diabetes or abnormal glucose metabolism.
As part of the AusDiab study, retinal photography was taken at baseline and after five years in 1,022 individuals aged 25 years and older. Retinal vessel caliber was measured from baseline photographs using a computer-based method. Retinopathy lesions detected at baseline and after five years were confirmed using side-by-side grading. Logistic regression was used to calculate the odds ratios (OR) of the 5-year cumulative prevalence of retinopathy lesions associated with baseline retinal vessel caliber, adjusting for age, gender, glycosylated hemoglobin, glucose metabolism status (normal, impaired fasting glucose [IFG] or impaired glucose tolerance [IGT], diabetes), systolic blood pressure, body mass index, total cholesterol and smoking.
Overall, the 5-year cumulative prevalence of retinopathy lesions was 8.2%. Among individuals with normal, IFG/IGT, and diabetes, the cumulative prevalence rates were 6.3%, 4.2%, and 16.4%, respectively. Larger retinal arteriolar caliber was associated with an increased likelihood of having retinopathy lesions (OR=1.4, 95% confidence intervals [CI] 0.7-2.6 for the middle, and OR=2.3, CI 1.1-4.5 for the widest compared to narrowest arteriolar caliber tertile). Retinal venular caliber was not associated with the prevalence of retinopathy lesions (OR=1.2, CI 0.6-2.2 for the middle and OR=1.1, CI 0.5-2.2 for the widest compared to narrowest venular caliber tertile).
Wider retinal arteriolar caliber was related to 5-year cumulative prevalence of isolated retinopathy lesions, independent of other risk factors.
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