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K. Warren, B. A. Blodi, M. S. Ip, I. U. Scott, N. Oden, P. VanVeldhuisen, Standard Care vs Corticosteroid for Retinal Vein Occlusion Study Group; Clinic vs. Reading Center Evaluation of Dense Retinal Hemorrhage at Baseline in the SCORE Branch Retinal Vein Occlusion (BRVO) Study. Invest. Ophthalmol. Vis. Sci. 2007;48(13):3087.
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To compare baseline clinic determination of presence/absence of dense macular hemorrhage (DH) in SCORE/BRVO patients to area of retinal hemorrhage as estimated by the UW Fundus Photograph Reading Center (FPRC).
The SCORE study consists of two multicenter trials comparing safety and efficacy of preservative-free intravitreal triamcinolone acetonide injections vs. standard care for macular edema associated with branch (BRVO) and central retinal vein occlusion (CRVO). Treatment for patients assigned to standard care in the BRVO study is either immediate grid laser treatment or deferral of laser due to dense blood in the macula. We compared the ophthalmologist’s initial assessment of presence/absence of DH in 206 consecutive patients enrolled in the SCORE/BRVO study to the FPRC assessment of area of retinal hemorrhage (RH) and retinal thickening (RT). Eyes were evaluated for extent of RH and RT by imposing the ETDRS macular grid and estimating the percent of each subfield involved. Subfield results were combined by algorithm to yield overall areas of RH and RT within concentric regions.
In the SCORE/BRVO study, 140 patients without DH and 66 patients with DH were available for analysis. Patients classified by clinicians with DH were determined by FPRC to have significantly greater area of RH than those without DH. *All comparisons p<0.0002 by T-test.
In the SCORE/BRVO study to date, there is excellent association at baseline between clinician determination of presence/absence of dense macular hemorrhage and area of retinal hemorrhage as determined at the FPRC.
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