May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Ocular Blood Flow Changes in Retinopathy of Prematurity With Plus Disease as Measured by Color Doppler Imaging
Author Affiliations & Notes
  • C. Hauch
    Ophthalmology, Saarland University, Homburg, Germany
  • A. Harris
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana
  • C. Jonescu-Cuypers
    Ophthalmology, Saarland University, Homburg, Germany
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana
  • B. Siesky
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana
  • L. McCranor
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana
  • B. Kaesmann-Kellner
    Ophthalmology, Saarland University, Homburg, Germany
  • B. Seitz
    Ophthalmology, Saarland University, Homburg, Germany
  • D. Neely
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana
  • Footnotes
    Commercial Relationships C. Hauch, None; A. Harris, None; C. Jonescu-Cuypers, None; B. Siesky, None; L. McCranor, None; B. Kaesmann-Kellner, None; B. Seitz, None; D. Neely, None.
  • Footnotes
    Support None.
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 3095. doi:https://doi.org/
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      C. Hauch, A. Harris, C. Jonescu-Cuypers, B. Siesky, L. McCranor, B. Kaesmann-Kellner, B. Seitz, D. Neely; Ocular Blood Flow Changes in Retinopathy of Prematurity With Plus Disease as Measured by Color Doppler Imaging. Invest. Ophthalmol. Vis. Sci. 2007;48(13):3095. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose:: To evaluate the changes in ocular blood flow as measured by color Doppler imaging (CDI) in preterm infants with retinopathy of prematurity (ROP) before and after development of plus disease.

Methods:: Sixteen high risk preterm infants with birth mean weight of 675.7 grams with a mean baseline gestational age of 174.6 + 8.98 days underwent blood flow measurements with CDI. Measurements focused on the ophthalmic artery (OA) and the central retinal artery (CRA) at baseline and at the time of first plus disease occurrence. Measured parameters were peak systolic velocity (PSV), end diastolic velocity (EDV) and resistive index (RI). Differences between both measurements were statistically evaluated by student-t-tests.

Results:: Analysis showed significant differences between baseline and time point of plus disease occurrence for the left eye CRA PSV (p=0.05) and left eye OA RI (p=0.05). Of the 16 infants examined in this study, there were no additional significant differences for all other examined parameters.

Conclusions:: These findings suggest that CDI indicates possible higher vascular resistance to blood flow in the retrobulbar blood vessels of premature infants with ROP and plus disease.

Keywords: imaging/image analysis: clinical • retinal development • optic flow 
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