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R. De Santis, D. Lepore, M. M. Pagliara, F. Molle, C. Angora, L. Orazi, A. Baldascino, F. Lafranceschina, M. Laguardia, E. Balestrazzi; Fluorangiographic Findings in Type 1 and Type 2 ROP. Invest. Ophthalmol. Vis. Sci. 2007;48(13):3111.
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to evaluate fluorescein angiographic findings in ROP undergoing laser treatment and compare with laser outcomes.
starting from Dec‘04 RETCAM digital fluorescein angiography (Massie Lab., Pleasanton, CA) became available for ROP screening in the neonatal intensive care unit at the Catholic University Hospital in Rome. Until Sep ‘06 135 inborn preterm with gestational age (GA) ≤32 wks and/or a birth weight (BW) ≤1500gr were screened for ROP. The mean BW was 1176.3 gr. (range 550-2150gr.) and the mean GA was 29.4 wks (range 24-33wks). ROP was diagnosed in 51 infants (mean BW 904.1gr, GA 27.6wks). 34 eyes (17 babies; mean BW 698.5 gr., mean GA 25.9wks) type1 ROP were treated at pre-threshold level. Five eyes (3 babies; mean BW 804.4 gr., mean GA 26.1 wks), classified as type 2, reached "classical" threshold" were also treated. Digital fluorescein angiography was performed before treatment.
fluorescein showed a variable arm to eye transit time; common features for all ROP were good visualization of junction between vascular and avascular retina, also due to intense dye leakage. Zone I ROP showed abnormal vessels branching and capillaries formation near the ridge. Shunts and large capillary free formation were also observed. In 12 eyes in zone I (75%) areas of hypo perfusion with significant dye leakage inside vascularised retina were observed.
Fluorescein angiography showed that abnormal vascularization also occurs inside vascularised retina. Together with other fluorangiographic signs these could be interpreted as pathologic vasculogenesis occurring inside zone I ROP.
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