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S. C. Reddy, D. Xing, S. Arthur, N. Harizman, S. Dorairaj, R. Ritch, J. M. Liebmann; HRT III Glaucoma Probability Score (GPS) and Moorfields Regression Analysis (MRA) in Eyes With Glaucomatous Visual Field Loss. Invest. Ophthalmol. Vis. Sci. 2007;48(13):3323.
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To compare the sensitivity and specificity of the HRT III GlaucomaProbability Score (GPS) and Moorfields Regression Analysis (MRA)across the spectrum of glaucomatous visual field loss.
Normal subjects and glaucoma patients underwent a complete eyeexamination, standard achromatic perimetry (SITA-SAP), and HRTIII imaging within 6 months. Normal subjects had no evidenceof glaucoma and 2 consecutive normal visual fields (VF) in botheyes (PSD >5% and GHT within normal limits or borderline).Glaucoma patients had VF loss (PSD <5% or GHT outside normallimits) on 2 consecutive VFs. An abnormal global MRA was definedas outside the 99.9% confidence limits and abnormal GPS as ≥0.64.
258 subjects were enrolled. See Tables 1 and 2.Table 1. Patientdata.Table 2. Sensitivityand specificity (%)
Specificity for MRA and GPS are similar. MRA offers slightlybetter sensitivity across the glaucoma spectrum in eyes withvisual field loss. GPS, which does not require contour lineplacement, may have a potential role in screening for severeglaucomatous damage.
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