HRT III Glaucoma Probability Score (GPS) and Moorfields Regression Analysis (MRA) in Eyes With Glaucomatous Visual Field Loss

Abstract

 

Purpose:

 

To compare the sensitivity and specificity of the HRT III GlaucomaProbability Score (GPS) and Moorfields Regression Analysis (MRA)across the spectrum of glaucomatous visual field loss.

 

Methods:

 

Normal subjects and glaucoma patients underwent a complete eyeexamination, standard achromatic perimetry (SITA-SAP), and HRTIII imaging within 6 months. Normal subjects had no evidenceof glaucoma and 2 consecutive normal visual fields (VF) in botheyes (PSD >5% and GHT within normal limits or borderline).Glaucoma patients had VF loss (PSD <5% or GHT outside normallimits) on 2 consecutive VFs. An abnormal global MRA was definedas outside the 99.9% confidence limits and abnormal GPS as ≥0.64.

 

Results:

 

258 subjects were enrolled. See Tables 1 and 2.Table 1. Patientdata.Table 2. Sensitivityand specificity (%) 

 

 

Conclusions:

 

Specificity for MRA and GPS are similar. MRA offers slightlybetter sensitivity across the glaucoma spectrum in eyes withvisual field loss. GPS, which does not require contour lineplacement, may have a potential role in screening for severeglaucomatous damage.

 

Keywords: imaging/image analysis: clinical • optic disc