May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Evaluation of Optical Coherence Tomography Measurement of Glaucoma Progression
K. Sung; G. Wollstein; H. Ishikawa; R. A. Bilonick; L. Kagemann; M. L. Gabriele; K. A. Townsend; C. Mattox; J. G. Fujimoto; J. S. Schuman
Author Affiliations & Notes
  • K. Sung
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
  • G. Wollstein
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
  • H. Ishikawa
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
  • R. A. Bilonick
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
  • L. Kagemann
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
  • M. L. Gabriele
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
  • K. A. Townsend
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
  • C. Mattox
    Ophthalmology, New England Eye Center, Tufts Uninersity School of Medicine, Boston, Massachusetts
  • J. G. Fujimoto
    Dept. of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts
  • J. S. Schuman
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
  • Footnotes
    Commercial Relationships K. Sung, None; G. Wollstein, Carl Zeiss Meditec, Inc, R; H. Ishikawa, Carl Zeiss Meditec, Inc, R; R.A. Bilonick, None; L. Kagemann, None; M.L. Gabriele, None; K.A. Townsend, None; C. Mattox, None; J.G. Fujimoto, Carl Zeiss Meditec, Inc, P; J.S. Schuman, Carl Zeiss Meditec, Inc, P; Carl Zeiss Meditec, Inc, Alcon, Allergan, Merck, Heidelberg, Clarity, R; Carl Zeiss Meditec Inc, Alcon, Allergan, Merck, Optovue, Heidelberg Engineering, F.
  • Footnotes
    Support NIH EY13178, EY11289, EY08098, EY13078; NSF ECS-0119452, BES-0522845; AFOSRFA9550-040-1-0011; MFEL FA9550-040-1-0046; Eye and Ear Foundation(Pittsburgh, PA), Research to Prevent Blindness
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 3337. doi:
  • Views
  • Share
  • Tools
    • Alerts
      User Alerts
      You are adding an alert for:
      Evaluation of Optical Coherence Tomography Measurement of Glaucoma Progression
      You will receive an email whenever this article is corrected, updated, or cited in the literature. You can manage this and all other alerts in My Account
      The alert will be sent to:
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation
      Citation

      K. Sung, G. Wollstein, H. Ishikawa, R. A. Bilonick, L. Kagemann, M. L. Gabriele, K. A. Townsend, C. Mattox, J. G. Fujimoto, J. S. Schuman; Evaluation of Optical Coherence Tomography Measurement of Glaucoma Progression. Invest. Ophthalmol. Vis. Sci. 2007;48(13):3337.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

      ×
    • Get Permissions
  • Supplements
Abstract

Purpose:: To assess the optical coherence tomography (OCT; StratusOCT, Carl Zeiss Meditec, Dublin, CA) measurement of glaucoma progression.

Methods:: 44 glaucomatous and 8 glaucoma suspect eyes of 32 subjects with at least 4 reliable visual fields (VF) and 4 qualified OCT scans were enrolled. VF progression was defined subjectively by 2 glaucoma experts assessment or by a 2dB decline of VF mean deviation (MD) from baseline value. OCT progression was defined as retinal nerve fiber layer (RNFL) thinning beyond the 95% confidence interval of reproducibility error of OCT RNFL thickness measurements as compared to baseline. The slope of RNFL thickness change over time was determined by a mixed effects model. The model accounted for the scan quality.

Results:: Average age at baseline was 69.0±12.0 years and the mean follow-up duration was 3.1±0.7 years (range:1.6-4.6 years). The average number of VFs was 5.6±1.6 and of OCTs was 5.5±1.1. Baseline average VF MD was -6.6±6.7dB, while last visit VF MD was -6.7±6.4dB. 18 eyes progressed by VF subjective assessment, 7 eyes progressed by VF MD criteria and 10 eyes by OCT RNFL; 3 eyes progressed by both VF subjective assessment and OCT RNFL, and 2 eyes by both VF MD criteria and OCT RNFL. The estimated probability of progression was higher for OCT, but the difference was not significant (p=0.98). The estimated slope of RNFL thickness for eyes that were defined as progressors by subjective VF assessment was -0.84 microns/year and for non-progressors -0.35 microns/year (p=0.20).

Conclusions:: OCT glaucoma progression analysis demonstrated poor agreement between functional (VF) and structural (OCT) progression. These findings suggest that structural and functioanl glaucomatous changes often may not be temporally coincident.

Clinical Trial:: www.clinicaltrials.gov NCT00343746.

Keywords: imaging/image analysis: clinical • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • nerve fiber layer 
© 2007, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×
This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy.Accept