May 2007
Volume 48, Issue 13
ARVO Annual Meeting Abstract  |   May 2007
Combination Therapy Using Verteporfin (PDT) and Pegaptanib Injections for Treatment of Exudative AMD
Author Affiliations & Notes
  • J. D. Holweger
    Loma Linda University, Loma Linda, California
  • E. D. Roth
    Grene Vision Group, Wichita, Kansas
  • I. Ahmad
    Department of Ophthalmology, University of Nebraska Medical Center, Omaha, Nebraska
  • D. M. Chacko
    Grene Vision Group, Wichita, Kansas
  • Footnotes
    Commercial Relationships J.D. Holweger, None; E.D. Roth, None; I. Ahmad, None; D.M. Chacko, None.
  • Footnotes
    Support None.
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 3363. doi:
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    • Get Citation

      J. D. Holweger, E. D. Roth, I. Ahmad, D. M. Chacko; Combination Therapy Using Verteporfin (PDT) and Pegaptanib Injections for Treatment of Exudative AMD. Invest. Ophthalmol. Vis. Sci. 2007;48(13):3363.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose:: To examine the effectiveness of a combination therapy of intravitreal pegaptanib injections and verteporfin photodynamic therapy (PDT-V) in treating exudative age-related macular degeneration.

Methods:: Retrospective review of 48 eyes of 47 patients with all types of exudative macular degeneration (average lesion size of 3012 microms) treated with a combination of PDT-V and .03mg pegaptanib injections. Most patients were treated every 3 to 4 weeks by alternating PDT-V with injections. The average treatment duration and follow up was 16 months with a median of 12 months.

Results:: Sixteen eyes (33%) gained an average of 24.8 letters while 27 eyes (56.3%) lost an average of 36.3 letters. The average pre-treatment vision was 20/160-2 (range: HM to 20/20) while the average post-treatment visual acuity was 20/300 (range: CF to 20/30). Twenty-eight eyes (58%) lost less than 15 letters of visual acuity. At their last checkup, 26 eyes had a visual acuity of 20/100 or better.

Conclusions:: Combination therapy may be more effective than monotherapy in improving vision. It is very effective in reducing leakage and maintaining visual acuity >20/100.

Keywords: age-related macular degeneration • photodynamic therapy • injection 

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