May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Quantitative Analysis of Photoreceptor Impairment by High Resolution, Three-Dimensional Spectral Optical Coherence Tomography
Author Affiliations & Notes
  • M. Szkulmowski
    Institute of Physics, Nicolaus Copernicus University, Torun, Poland
  • B. Sikorski
    Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland
  • T. Bajraszewski
    Institute of Physics, Nicolaus Copernicus University, Torun, Poland
  • J. J. Kaluzny
    Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland
  • J. S. Schuman
    Department of Ophthalmology, UPMC Eye Center, Pittsburgh, Pennsylvania
  • J. S. Duker
    New England Eye Center, Tufts University, Boston, Massachusetts
  • J. G. Fujimoto
    Dept. of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts
  • A. Kowalczyk
    Institute of Physics, Nicolaus Copernicus University, Torun, Poland
  • M. Wojtkowski
    Institute of Physics, Nicolaus Copernicus University, Torun, Poland
  • Footnotes
    Commercial Relationships M. Szkulmowski, OPTOPOL Technology, C; B. Sikorski, None; T. Bajraszewski, OPTOPOL Technology, C; J.J. Kaluzny, None; J.S. Schuman, None; J.S. Duker, None; J.G. Fujimoto, None; A. Kowalczyk, OPTOPOL Technology, C; M. Wojtkowski, OPTOPOL Technology, C.
  • Footnotes
    Support This research is supported by Polish government - scientific grants for years 2005-2008
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 3447. doi:https://doi.org/
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      M. Szkulmowski, B. Sikorski, T. Bajraszewski, J. J. Kaluzny, J. S. Schuman, J. S. Duker, J. G. Fujimoto, A. Kowalczyk, M. Wojtkowski; Quantitative Analysis of Photoreceptor Impairment by High Resolution, Three-Dimensional Spectral Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2007;48(13):3447. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose:: To demonstrate the capability of high-speed spectral optical coherence tomography (SOCT) to quantitatively analyze the distribution and density of damaged photoreceptors in retinal diseases. To present novel scanning protocols and post-processing tools enabling quantitative analysis of photoreceptors.

Methods:: The specialized measurement protocols and advanced layer segmentation software has been developed and applied to data obtained in the ophthalmology department. We have also introduced novel methods of analysis and visualization of the individual segmented layer representing the complex of RPE and outer segments of photoreceptors. Data presented in this contribution are obtained with the prototype high-resolution, high speed SOCT system constructed at the Nicolaus Copernicus University, operating on an every-day basis at the Ophthalmology Department of the Collegium Medicum in Bydgoszcz,Poland.

Results:: In vivo high-speed, ultrahigh resolution SOCT imaging has been performed in more than 470 eyes of 290 patients with various retinal diseases. The features of photoreceptors impairment or atrophy caused mostly by acquired reasons (AMD, MEWDS, AZOOR, APMPPE) were observed in 16 eyes. In all cases we observed dramatic changes of reflectivity of the junction between inner and outer segments of photoreceptors (IS/OS). We present contour maps indicating the region of photoreceptor impairment. These en-face maps are correlated with ICG and /or Fluorescein Angiography.

Conclusions:: Using three dimensional SOCT and novel anlysis tools we were able to find regions of probable impairments of photoreceptors, which well correlate to ICG and FA. We believe that the novel technology can provide a better understanding of disease pathogenesis, provide more sensitive diagnostic indicators of early disease by quantitative analysis of light reflectivity scattered back from the photoreceptor layers. It is also sensitive for small focal changes, which can be easily missed by other imaging tehnologies.

Keywords: photoreceptors • imaging/image analysis: clinical • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) 
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