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J. C. Erie, S. V. Patel, E. J. Winter, C. B. Nau, J. W. McLaren, W. M. Bourne; Recovery of Corneal Subbasal Nerve Density After Penetrating Keratoplasty. Invest. Ophthalmol. Vis. Sci. 2007;48(13):3501.
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© ARVO (1962-2015); The Authors (2016-present)
To measure subbasal nerve density in clear penetrating corneal grafts and to determine the change in density with time after penetrating keratoplasty.
Thirty clear grafts (30 patients) after penetrating keratoplasty were examined by confocal microscopy. Time after corneal transplantation varied from 2-30 years, with a uniform distribution of grafts during each consecutive 5-year interval. Subbasal nerve fiber bundles were identified in confocal images and subbasal nerve density was measured in the central cornea (visible length of nerve/frame area) and expressed as µm/mm2. Differences between nerve densities post-operatively (5-year intervals) for up to 30 years were compared to densities of 42 normal corneas by using the Wilcoxon rank-sum test (Bonferroni-adjusted for multiple comparisons).
* Rank sum test, compared to normal corneas (Bonferroni-adjusted x 6) Minimum Detectable Difference 2,836 µm/mm2 (α=0.008, ß=0.10)
Corneal subbasal nerve density after penetrating keratoplasty remains markedly decreased through 30 years compared to normal corneas.
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