May 2007
Volume 48, Issue 13
ARVO Annual Meeting Abstract  |   May 2007
Pathologic Classification of Leiomyomas of the Ocular Adnexa
Author Affiliations & Notes
  • S. A. McCormick
    New York Eye & Ear Infirmary, New York, New York
    Department of Pathology,
  • R. W. Sedeek
    New York Eye & Ear Infirmary, New York, New York
    Department of Ophthalmology,
  • Footnotes
    Commercial Relationships S.A. McCormick, None; R.W. Sedeek, None.
  • Footnotes
    Support None.
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 3588. doi:
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      S. A. McCormick, R. W. Sedeek; Pathologic Classification of Leiomyomas of the Ocular Adnexa. Invest. Ophthalmol. Vis. Sci. 2007;48(13):3588.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose:: Multiple case reports and a few small series of leiomyomas of the ocular adnexa have been reported, but none have addressed subclassification of this tumor based on tissue of origin. We review the features of 5 cases from NYEEI which allow sub-classification based on histomorphology.

Methods:: Retrospective review of 5 new cases diagnosed at NYEEI between 1990 and 2006 and review of 8 confirmed cases from the modern literature.

Results:: These thirteen cases of leiomyoma were the only examples authenicated by immunohistochemical expression of smooth muscle specific antigen (SMA). Neural tumors and solitary fibrous tumor were ruled out by S-100 and CD34 negativity in our cases. The tumors' histomorphology correlated with their anatomic tissue of origin, namely vascular smooth muscle, arrector pili muscle or smooth muscle retractors of the upper or lower eyelid.

Conclusions:: Leiomyoma is a rare neoplasm of the ocular adnexa which may originate in three possible smooth muscle tissues found in this region. All are SMA positive and have histomorphology which correlates with the tissue of origin.

Keywords: immunohistochemistry • tumors • orbit 

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