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J. Nguyen, A. Husain, B. Esmaeli; Squamous Cell Carcinoma of Anophthalmic Socket in Patients With Chronic Ocular Prosthesis Use. Invest. Ophthalmol. Vis. Sci. 2007;48(13):3595.
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Conjunctival squamous cell carcinoma (SCCA) is a very uncommon cancer in the anophthalmic socket. We report 2 patients in whom SCCA developed in their anophthalmic socket more than 44 years after enucleation and chronic use of an ocular prosthesis.
The clinical records, histopathologic sections, and the surgical records in each case were reviewed.
There was no history of cigarette smoking, or exposure to HIV or HPV. The presenting symptoms included new onset of discharge and a poor fitting prosthesis. Both patients had invasive SCCA of the anophthalmic socket with primary involvement of the bulbar conjunctiva confirmed via a biopsy. Magnetic resonance imaging demonstrated extension of tumor into the deep orbital tissues. In each case the eyelid skin and palpebral conjunctiva were not involved. The systemic metastatic work-up including ultrasonography of the regional lymph nodes were negative. Both patients underwent an orbital exenteration after the diagnosis of invasive conjunctival SCCA was established.
In these 2 patients with anophthalmic socket and full-time prosthesis wear for over 40 years, chronic irritation and contact with the ocular prosthesis may be a putative risk factor for development of conjunctival SCCA. Regular examination of the anophthalmic socket in chronic prosthesis users is prudent to detect conjunctival SCCA at the earliest possible stage.
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