May 2007
Volume 48, Issue 13
ARVO Annual Meeting Abstract  |   May 2007
Expression of Hedgehog Family Protein in Ocular Surface Neoplasm
Author Affiliations & Notes
  • K. Fujita
    Ophthalmology, Wakayama Medical University, Wakayama, Japan
  • Footnotes
    Commercial Relationships K. Fujita, None.
  • Footnotes
    Support None.
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 3598. doi:
  • Views
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      K. Fujita; Expression of Hedgehog Family Protein in Ocular Surface Neoplasm. Invest. Ophthalmol. Vis. Sci. 2007;48(13):3598.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements

Purpose:: The hedgehog (Hh) family of genes, sonic hedgehog (Shh), Indian hedgehog (Ihh), and desert hedgehog (Dhh) encode signaling molecules that regulate multiple functions during organ development and in neoplastic diseases.To examine if cell of ocular surface neoplasm express Sonic hedgehog (Shh), Indian hedgehog (Ihh), and desert hedgehog (Dhh) a morphogen which is also involved in cell proliferation regulation.

Methods:: Samples of human conjunctival tissue(n=3), pterygium(n=3) ,papilloma(n=3), squamous cell carcinoma(n=3) were included and immunohistochemically examained.

Results:: Conjunctival epithelial cells were weakly stained for Shh,Ihh,Dhh ,Gli3, a signal transmitter from the Shh receptor, and proliferating nuclear cell antigen (PCNA). whereas cells in a papillpma and squamous cell carcinoma were markedly labeled with the antibody. Staining pattern of epithelial cells in pterygium was similar to that seen in uninjured conjunctiva.

Conclusions:: Shh, Ihh,Dhh was constitutively expressed in epithelial cells of the conjunctiva. Shh, Ihh,Dhh was up-regulated in ocular surface epithelial neoplasm. The hedgehog (Hh) family modulates cell proliferation in ocular surface epithelial neoplastic tissues

Clinical Trial:: kyoko

Keywords: tumors • signal transduction • conjunctiva 

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.