May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Correlation Between Macular Volume and Focal Macular Electroretinogram in Patients With Retinitis Pigmentosa
Author Affiliations & Notes
  • T. Sugita
    Department of Opthalmology, Nagoya University School of Medicine, Nagoya, Japan
  • M. Kondo
    Department of Opthalmology, Nagoya University School of Medicine, Nagoya, Japan
  • Y. Nakamura
    Department of Opthalmology, Nagoya University School of Medicine, Nagoya, Japan
  • C. H. Piao
    Department of Opthalmology, Nagoya University School of Medicine, Nagoya, Japan
  • Y. Ito
    Department of Opthalmology, Nagoya University School of Medicine, Nagoya, Japan
  • H. Terasaki
    Department of Opthalmology, Nagoya University School of Medicine, Nagoya, Japan
  • Footnotes
    Commercial Relationships T. Sugita, None; M. Kondo, None; Y. Nakamura, None; C.H. Piao, None; Y. Ito, None; H. Terasaki, None.
  • Footnotes
    Support 18591913 (MK), and 18390466 (HT) from the Ministry of Education, Science, Sports and Culture, Japan.
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 3728. doi:https://doi.org/
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    • Get Citation

      T. Sugita, M. Kondo, Y. Nakamura, C. H. Piao, Y. Ito, H. Terasaki; Correlation Between Macular Volume and Focal Macular Electroretinogram in Patients With Retinitis Pigmentosa. Invest. Ophthalmol. Vis. Sci. 2007;48(13):3728. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose:: To determine whether there is any correlation between the macular volume and the amplitude of focal macular electroretinogramus (FMERGs) in patients with retinitis pigmentosa (RP).

Methods:: Twenty-six eyes of 26 patients with RP (9 men, 17 women; mean age, 41.7 years), who had visual acuity of 0.3 or better, were studied. FMERGs were elicited by 15-degrees stimulus spot centered on the fovea under direct fundus observation using a modified infrared fundus camera. The macular volume was measured in a 6-mm diameter central retinal region by optical coherence tomography (Stratus OCT, Carl Zeiss Meditec). The FMERGs and macular volumes were also recorded from 20 age-matched normal controls.

Results:: In RP patients, the mean macular volume was 5.98±0.60 mm3, and the mean b-wave amplitude was 1.06±1.09 µV. Both values were significantly smaller in RP patients than those in normal controls (P<0.05). There was a significant correlation between the macular volume and the b-wave amplitude (Spearman's rank correlation; P=0.004, ρ=0.571). FMERGs were detectable for all patients who had a macular volume of >6.5 mm3.

Conclusions:: These results suggest that the decrease in the FMERGs in RP patients is due to a degeneration of the macular region of the retina.

Keywords: retinal degenerations: hereditary • electrophysiology: clinical • imaging/image analysis: clinical 
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