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H. Nakamura, N. Kawagoe, A. Oishi, M. Kurimoto, A. Otani, N. Yoshimura; Evaluation of Cone Dysfunction in Retinitis Pigmentosa by Focal Electroretinograms. Invest. Ophthalmol. Vis. Sci. 2007;48(13):3731.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate the clinical correlation between focal electroretinograms (ERG) and optical coherence tomography (OCT) in patients with retinitis pigmentosa.
All 8 patients with retinitis pigmentosa had best corrected Snellen visual acuities of 25/20 to 10/20 and central Goldmann visual fields (V4e target) of greater than 10 degrees. We recorded focal ERGs and OCT in the central regions from 8 eyes (8 patients). OCT was examined by using Fourier domain OCT (FD-OCT) and OCT3000. OCT was classified into 3 groups based on the structure of the photoreceptor inner/outer segments (IS/OS) junction: group 1, intact; group 2, partially distinct; and group 3, absent. Focal ERGs were elicited by a 15 degrees stimulus centered on the fovea and monitored by an infrared fundus camera. The amplitudes and implicit times of the a- and b-waves and oscillatory potentials (OPs) were compared with age-matched normal control data.
We recorded a- and b-waves and OPs in 8 eyes of all 8 patients (group 1, 2 eyes; group 2, 4 eyes; and group 3, 2 eyes). Two patients in group 1 showed subnormal focal ERG. The mean amplitudes (±S.D.), respectively, were: a wave, 96.4±25.3 %; b wave, 69.9±21.7 % and OP, 66.7±23.6 %. The mean implicit times were within normal. Patients in group 1 had a central visual field of at least 30 degrees and a Snellen acuity between 25/20 and 16/20. All 4 patients in group 2 showed reduced and delayed focal ERG (amplitude: a wave, 31.3±6.3 %; b-wave, 18.7±8.2 %; OP, 22.4±12.4 % and implicit time: a wave, 123.9±31.6 %; b wave, 104.8±10.4 %; OP, 116.2±11.3 %). Patients in group 2 had a visual field of 10-40 degrees and a Snellen acuity between 24/20 and 12/20. Two patients in group 3 showed non-recordable focal ERG. Patients in group 3 had a visual field of 10-30 degrees and a Snellen acuity between 14/20 and 10/20. Patients in group 3 had a loss of visual acuity more than those of group 1 and 2. There was a correlation between focal ERG and OCT.
These results suggest that focal ERG is useful to evaluate cone dysfunction in the macula of patients with retinitis pigmentosa.
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