May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Evaluation of Cone Dysfunction in Retinitis Pigmentosa by Focal Electroretinograms
H. Nakamura; N. Kawagoe; A. Oishi; M. Kurimoto; A. Otani; N. Yoshimura
Author Affiliations & Notes
  • H. Nakamura
    Ophthalmology, Kyoto University, Kyoto, Japan
  • N. Kawagoe
    Ophthalmology, Kyoto University, Kyoto, Japan
  • A. Oishi
    Ophthalmology, Kyoto University, Kyoto, Japan
  • M. Kurimoto
    Ophthalmology, Kyoto-Katsura Hospital, Kyoto, Japan
  • A. Otani
    Ophthalmology, Kyoto University, Kyoto, Japan
  • N. Yoshimura
    Ophthalmology, Kyoto University, Kyoto, Japan
  • Footnotes
    Commercial Relationships H. Nakamura, None; N. Kawagoe, None; A. Oishi, None; M. Kurimoto, None; A. Otani, None; N. Yoshimura, None.
  • Footnotes
    Support None.
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 3731. doi:
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      H. Nakamura, N. Kawagoe, A. Oishi, M. Kurimoto, A. Otani, N. Yoshimura; Evaluation of Cone Dysfunction in Retinitis Pigmentosa by Focal Electroretinograms. Invest. Ophthalmol. Vis. Sci. 2007;48(13):3731.

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Abstract

Purpose:: To investigate the clinical correlation between focal electroretinograms (ERG) and optical coherence tomography (OCT) in patients with retinitis pigmentosa.

Methods:: All 8 patients with retinitis pigmentosa had best corrected Snellen visual acuities of 25/20 to 10/20 and central Goldmann visual fields (V4e target) of greater than 10 degrees. We recorded focal ERGs and OCT in the central regions from 8 eyes (8 patients). OCT was examined by using Fourier domain OCT (FD-OCT) and OCT3000. OCT was classified into 3 groups based on the structure of the photoreceptor inner/outer segments (IS/OS) junction: group 1, intact; group 2, partially distinct; and group 3, absent. Focal ERGs were elicited by a 15 degrees stimulus centered on the fovea and monitored by an infrared fundus camera. The amplitudes and implicit times of the a- and b-waves and oscillatory potentials (OPs) were compared with age-matched normal control data.

Results:: We recorded a- and b-waves and OPs in 8 eyes of all 8 patients (group 1, 2 eyes; group 2, 4 eyes; and group 3, 2 eyes). Two patients in group 1 showed subnormal focal ERG. The mean amplitudes (±S.D.), respectively, were: a wave, 96.4±25.3 %; b wave, 69.9±21.7 % and OP, 66.7±23.6 %. The mean implicit times were within normal. Patients in group 1 had a central visual field of at least 30 degrees and a Snellen acuity between 25/20 and 16/20. All 4 patients in group 2 showed reduced and delayed focal ERG (amplitude: a wave, 31.3±6.3 %; b-wave, 18.7±8.2 %; OP, 22.4±12.4 % and implicit time: a wave, 123.9±31.6 %; b wave, 104.8±10.4 %; OP, 116.2±11.3 %). Patients in group 2 had a visual field of 10-40 degrees and a Snellen acuity between 24/20 and 12/20. Two patients in group 3 showed non-recordable focal ERG. Patients in group 3 had a visual field of 10-30 degrees and a Snellen acuity between 14/20 and 10/20. Patients in group 3 had a loss of visual acuity more than those of group 1 and 2. There was a correlation between focal ERG and OCT.

Conclusions:: These results suggest that focal ERG is useful to evaluate cone dysfunction in the macula of patients with retinitis pigmentosa.

Keywords: retinitis • electroretinography: clinical • photoreceptors 
© 2007, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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