May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Equivalent Refractive Indices of Isolated Human and Monkey Crystalline Lenses
Author Affiliations & Notes
  • D. Borja
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, Univ. of Miami School of Medicine, Miami, Florida
    Dept. of Biomedical Engineering, Univ. of Miami College of Engineering, Coral Gables, Florida
  • A. Rosen
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, Univ. of Miami School of Medicine, Miami, Florida
  • M. N. Hoang
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, Univ. of Miami School of Medicine, Miami, Florida
  • A. A. Amelinckx
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, Univ. of Miami School of Medicine, Miami, Florida
  • F. Manns
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, Univ. of Miami School of Medicine, Miami, Florida
    Dept. of Biomedical Engineering, Univ. of Miami College of Engineering, Coral Gables, Florida
  • R. Augusteyn
    Institute for Eye Research, Vision Cooperative Research Centre, Sydney, Australia
  • A. Ho
    Institute for Eye Research, Vision Cooperative Research Centre, Sydney, Australia
  • J.-M. Parel
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, Univ. of Miami School of Medicine, Miami, Florida
    Dept. of Biomedical Engineering, Univ. of Miami College of Engineering, Coral Gables, Florida
  • Footnotes
    Commercial Relationships D. Borja, None; A. Rosen, None; M.N. Hoang, None; A.A. Amelinckx, None; F. Manns, None; R. Augusteyn, None; A. Ho, None; J. Parel, None.
  • Footnotes
    Support NIH F31EY015395, EY014225; Florida Lions Eye Bank; Vision Cooperative Research Centre, Sydney, Australia; AMO Inc, Santa Ana, CA; NIH center grant P30-EY014801; Research to Prevent Blindness, Henri an
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 3817. doi:
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    • Get Citation

      D. Borja, A. Rosen, M. N. Hoang, A. A. Amelinckx, F. Manns, R. Augusteyn, A. Ho, J.-M. Parel; Equivalent Refractive Indices of Isolated Human and Monkey Crystalline Lenses. Invest. Ophthalmol. Vis. Sci. 2007;48(13):3817.

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Abstract
 
Purpose:
 

To determine if the difference in lens power between cynomolgus monkey and human lenses are due to differences in the equivalent refractive index.

 
Methods:
 

Measurements were performed on 13 human (26-82 years, average =47.0±18.5 years, and <5 days postmortem) and 24 cynomolgus monkeys (45-106 months, average =74.1±25.5 months, and <1 days postmortem) isolated lenses. The lenses were carefully extracted from whole globes to avoid capsular damage and immediately immersed in room temperature DMEM. Optical power was measured using a custom designed Badal lensmeter with an aperture of 3mm. The sagittal thickness was obtained from 20X undistorted sagittal view shadowphotographs. Visibly swollen or delaminated lenses in the shadowgraph images were excluded. Central radii of curvature and asphericity of the lens’ anterior and posterior surfaces were obtained by fitting conic functions to the central 6mm zone of the anterior and posterior profiles. Ray tracing simulations of the optical power measurements incorporating the measured lens biometric properties were used to determine the central equivalent refractive index of the isolated lenses

 
Results:
 

 

 
Conclusions:
 

There was no significant difference in equivalent refractive index between the two species. The higher optical power of the cynomolgus lens is due to its smaller radii of curvature.

 
Keywords: optical properties • comparative anatomy • aging: visual performance 
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