May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Biometry of the Primate Lens Capsule Pre-Post Endolenticular Evacuation ex vivo
Author Affiliations & Notes
  • J.-M. A. Parel
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida
    Biomedical Optics and Laser Laboratory, Biomedical Engineering, University of Miami, Coral Gables, Florida
  • N. M. Ziebarth
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida
    Biomedical Optics and Laser Laboratory, Biomedical Engineering, University of Miami, Coral Gables, Florida
  • D. Borja
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida
    Biomedical Optics and Laser Laboratory, Biomedical Engineering, University of Miami, Coral Gables, Florida
  • R. Jain
    Advanced Medical Optics, Inc., Santa Ana, California
  • E. Arrieta-Quintero
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida
    University Los Andes Hospital, Merida, Venezuela
  • F. Manns
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida
    Biomedical Optics and Laser Laboratory, Biomedical Engineering, University of Miami, Coral Gables, Florida
  • A. Ho
    VisionCRC, University of New South Wales, Sydney, Australia
  • Footnotes
    Commercial Relationships J.A. Parel, None; N.M. Ziebarth, None; D. Borja, None; R. Jain, Advanced Medical Optics, Inc., E; E. Arrieta-Quintero, None; F. Manns, None; A. Ho, None.
  • Footnotes
    Support NIH EY14225; FL Lions Eye Bank; Vision CRC, Sydney, Australia; AMO, Inc.; NSF Graduate Student Fellowship; NIH P30-EY014801 HIGHWIRE EXLINK_ID="48:5:3827:1" VALUE="EY014801" TYPEGUESS="GEN" /HIGHWIRE ; Research to Prevent Blindness; Henri and Flore Lesieur Foundation
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 3827. doi:https://doi.org/
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    • Get Citation

      J.-M. A. Parel, N. M. Ziebarth, D. Borja, R. Jain, E. Arrieta-Quintero, F. Manns, A. Ho; Biometry of the Primate Lens Capsule Pre-Post Endolenticular Evacuation ex vivo. Invest. Ophthalmol. Vis. Sci. 2007;48(13):3827. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose:: To determine if the capsular bag dimensions after endolenticular evacuation can be predicted from the natural lens dimensions.

Methods:: Experiments were performed on cadaver human (n=15, 8-76 years, <5 days postmortem) and cynomolgus monkey (n=19, 5.3-14 years, <2 days postmortem) eyes. The eyes were prepared by bonding 8 PMMA segments on the sclera after removal of conjunctiva, adipose, and muscle tissues. The globe was dissected leaving a lens-zonule-ciliary body-sclera section with intact hyaloid and anterior vitreous. The section was transferred to an optomechanical lens stretcher (Parel, EVAS I, ARVO 2002). The sclera between each segment was sectioned. Digital images of the lens were recorded through an operation microscope set at 10x. A mini-capsulorhexis (< 2mm diameter) was made in the peripheral region of the capsule, the lens content was removed, and the empty capsular bag diameter was measured on recorded digital images. The diameter of the natural lens and empty bag were compared. In 12 of the 19 cyno and 7 of the 15 human lenses, the diameter and thickness of the contralateral isolated natural lens were measured by shadowphotography. The surface area of the empty capsular bag was compared with the surface area of the contralateral eye, calculated using the equation of an ellipse

Results:: The diameter of the unstretched empty capsular bag increases as a function of age in both humans and cynomolgus monkeys (p=0.10 and p=0.002, respectively). The surface area of the empty capsular bag also increases as a function of age (p=0.10 human and p=0.02 cyno). The ratio of empty capsular bag diameter to natural lens diameter is constant for both species of all ages (ratio=1.08). The ratio for empty bag surface area to natural lens surface area is also constant for both species for all ages (ratio=0.83).

Conclusions:: The empty lens capsule diameter can be predicted from normative data on intact lenses.Support: NIH EY14225; Florida Lions Eye Bank; Vision CRC, Sydney Australia;AMO Inc, Santa Ana, CA;NSF Graduate Student Fellowship; NIH center grant P30-EY014801; Research to Prevent Blindness.; Henri and Flore Lesieur Foundation.

Keywords: presbyopia • aging • anatomy 
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