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B. J. Kaluzny, J. Kaluzny, M. Szkulmowski, A. Szkulmowska, I. Gorczynska, M. Wojtkowski, A. Kowalczyk; In vivo Imaging of the Corneal Dystrophies With Spectral Optical Coherence Tomography (SOCT). Invest. Ophthalmol. Vis. Sci. 2007;48(13):3875. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To demonstrate applicability of high-speed, high-resolution Spectral Optical Coherence Tomography (SOCT) to in vivo imaging of the corneal dystrophies. To introduce new two- and three-dimensional scanning protocols for architectural morphology imaging of these pathologies.
New high-speed Spectral OCT instrument constructed at Nicolaus Copernicus University (Torun, Poland) has been optimized for high resolution imaging of the anterior segment of the human eye in vivo. This instrument is based on Fourier domain detection, which enables increasing the speed of imaging by 60 times comparing to standard OCT techniques and high sensitivity (96 dB). In turn, high speed of the imaging device enables reconstructing three-dimensional information about ocular structures. Both central wavelength of the light source of 830nm and the spectral bandwidth of 70nm allow imaging of the ocular surface with high axial resolution of 4.5um. The prototype SOCT instrument works under clinical conditions in Ophthalmology Department (Collegium Medicum NCU, Bydgoszcz, Poland). Anterior segments of 25 patients with diagnosis of various corneal dystrophies have been examined with the aid of the instrument. All SOCT measurements were followed by a slit lamp examination, color digital photography and confocal microscopy (Confoscan, Nidek, Japan)
Our SOCT instrument provides high-resolution (4.5µm axial x 10µm transverse) tomograms composed of 1024 A-scans with acquisition time below 0.1 second. The quality of the acquired images is adequate for precise cross-sectional evaluation of various corneal dystrophies. Three-dimensional scanning protocols enable better visualization of architectural morphology. Moreover, en facecontour maps of corneal opacities distribution were created from 3-dimensional SOCT data.
SOCT allows high-resolution, two- and three-dimensional, cross-sectional imaging of various corneal dystrophies that can be useful in clinical evaluation and research. New instrument provides valuable information supplementary to this obtained by slit lamp examination and confocal microscopy.
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