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T. Miyai, K. Minami, R. Nejima, Y. Osakabe, M. Honbo, K. Miyata, S. Amano; Corneal Epithelial Thickness Measured by Optical Low Coherence Reflectometry Pachymeter. Invest. Ophthalmol. Vis. Sci. 2007;48(13):3879.
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© ARVO (1962-2015); The Authors (2016-present)
Optical Low Coherence Reflectometry (OLCR) pachymeter has been commercially available, which can be attached to a slit-lamp microscope and has the capabilities of non-contact measurement of central corneal thickness (CCT) as well as corneal epithelial thickness. The purpose of this study is to assess corneal epithelial thickness measurement by OLCR pachymeter in normal eyes and investigate factors correlated with the epithelial thickness.
Seventy eyes of 35 normal volunteers were included in this study. Age was 36.8 + 10.4 (range: 14 - 56) years. Mean UCVA was 1.17 (range: 0.3 to 1.5), and manifest refractive spherical equivalent (MRSE) was -0.1 + 0.5 D (range: -1.0 to 0.8). Corneal epithelial thickness was measured with OLCR pachymeter (Haag-Streit, Germany). CCT was measured with OLCR and conventional ultrasonic pachymeter. Axial length was measured with IOL master (Carl-Zeiss, Germany). All measurements were performed by a single examiner. Correlations of corneal epithelial thickness with age, MRSE, CCT, and axial length were examined by regression analysis. CCT measured by OLCR was used for regression analysis.
CCT was 535.5 + 26.1 micrometer (ultrasonic) and 530.6 + 26.1 micro (OLCR), both of them were significantly correlated (r=0.98, p<0.01). Corneal epithelial thickness measured with OLCR was 61.8 + 10.6 micrometer. Corneal epithelial thickness had significant correlation with age (r=0.38, p<0.01) and MRSE (r=0.27, p=0.02), but not with CCT and axial length.
Non-contact measurement of epithelial thickness as well as CCT was possible using OLCR pachymeter. In normal eyes, thickness of corneal epithelium measured by OLCR pachymeter increased as age increases and refraction is more hyperopic.
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