May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Thickness Measurement of the Posterior Lamella After Posterior Lamellar Keratoplasty, With the Anterior Segment Optical Coherence Tomography
Author Affiliations & Notes
  • M. E. J. Van Velthoven
    Ophthalmology, Univ of Amsterdam Acad Med Ctr, Amsterdam, The Netherlands
  • C. Biallosterski
    Ophthalmology, Univ of Amsterdam Acad Med Ctr, Amsterdam, The Netherlands
  • F. D. Verbraak
    Ophthalmology, Univ of Amsterdam Acad Med Ctr, Amsterdam, The Netherlands
  • I. J. E. van der Meulen
    Ophthalmology, Univ of Amsterdam Acad Med Ctr, Amsterdam, The Netherlands
  • G. R. J. Melles
    Netherlands Institute of Innovative Ocular Surgery, Rotterdam, The Netherlands
  • C. P. Nieuwendaal
    Ophthalmology, Univ of Amsterdam Acad Med Ctr, Amsterdam, The Netherlands
  • Footnotes
    Commercial Relationships M.E.J. Van Velthoven, None; C. Biallosterski, None; F.D. Verbraak, None; I.J.E. van der Meulen, None; G.R.J. Melles, None; C.P. Nieuwendaal, None.
  • Footnotes
    Support None.
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 3885. doi:https://doi.org/
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      M. E. J. Van Velthoven, C. Biallosterski, F. D. Verbraak, I. J. E. van der Meulen, G. R. J. Melles, C. P. Nieuwendaal; Thickness Measurement of the Posterior Lamella After Posterior Lamellar Keratoplasty, With the Anterior Segment Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2007;48(13):3885. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

To evaluate the posterior lamellar donor thickness measured with the Visante anterior segment OCT in patients with Fuchs’ endothelial dystrophy after posterior lamellar keratoplasty (PLK).

 
Methods:
 

Patients following PLK, with manually dissected donor lamellae, were measured with the new anterior segment OCT (Visante OCT, Carl Zeiss Meditec). Four cross-sectional scans were made in a radial pattern, 45° apart. Thickness measurements were done centrally, and at 1.5 and 3 mm at both sides from the center. Thickness measurements were correlated with postoperative best-corrected visual acuity (BCVA in Snellen).

 
Results:
 

Seventeen eyes of 15 patients were included in the study. Median (range) BCVA was 0.25 (0.01-0.40) pre-operative, and 0.5 (0.32-0.80) postoperatively. Median follow-up time was 15.5 months (range 5-32 months). Fifteen eyes showed improvement of visual acuity after PLK, no patients had loss of vision. Median (range) lamellar thickness (at 180°) was 117 (64-183) micron in the center, and increased significantly towards the periphery (142 (77-334) micron, 130 (59-267) micron, 134 (92-260 micron) and 178 (93-309 micron) at -3, -1.5, 1.5 and 3 mm from the center respectively; Figure 1A). A trend was seen showing better postoperative BCVA with thinner central posterior lamellae (Figure 1B). Thickening of the lamellae towards the periphery had no influence on BCVA.

 
Conclusions:
 

This study shows that PLK, with manually dissected lamellae, in patients with decompensated Fuchs’ endothelial dystrophy is a successful procedure. OCT measurements of the lamellar thickness showed significant variance in central thickness compared to peripheral thickness, but this had no influence on postoperative BCVA. A trend was seen towards better postoperative BCVA with a thinner center of the lamellae.  

 
Keywords: cornea: clinical science • imaging/image analysis: clinical 
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