May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
To Evaluate the Action of the Travoprost 0.004% in the Ocular Pulse Amplitude
Author Affiliations & Notes
  • R. A. Barros
    Glaucoma, ABC School of Medicine, São Paulo, Brazil
  • P. Y. Kitice
    Glaucoma, ABC School of Medicine, São Paulo, Brazil
  • T. H. C. Nunes
    Glaucoma, ABC School of Medicine, São Paulo, Brazil
  • R. Canovas
    Glaucoma, ABC School of Medicine, São Paulo, Brazil
  • W. G. Amorim
    Glaucoma, ABC School of Medicine, São Paulo, Brazil
  • J. R. Rehder
    Glaucoma, ABC School of Medicine, São Paulo, Brazil
  • Footnotes
    Commercial Relationships R.A. Barros, None; P.Y. Kitice, None; T.H.C. Nunes, None; R. Canovas, None; W.G. Amorim, None; J.R. Rehder, None.
  • Footnotes
    Support None.
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 3932. doi:https://doi.org/
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      R. A. Barros, P. Y. Kitice, T. H. C. Nunes, R. Canovas, W. G. Amorim, J. R. Rehder; To Evaluate the Action of the Travoprost 0.004% in the Ocular Pulse Amplitude. Invest. Ophthalmol. Vis. Sci. 2007;48(13):3932. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose:: Ocular pulse amplitude (OPA) is the difference between minimum (diastolic) and maximum (systolic) values of the intraocular pressure (IOP). The Pascal dynamic contour tonometer (PDCT) is a new device that simultaneously measures IOP and OPA. The purpose of this study was to evaluate the action of Travoprost 0.004% in the OPA in patients with primary open-angle glaucoma (POAG) using PDCT.

Methods:: In this prospective study, we included 48 eyes of 30 patients with uncontrolled POAG with one medication or none. We started Travoprost 0.004% eye drops once at night for 30 days. IOP and OPA were measured using PDCT at the first visit and after one month in all patients. We also checked the IOP with Goldmann applanation tonometer (GAT).

Results:: At the first visit the mean IOP with GAT was 20.3 mmHg, with PDCT was 21.3 mmHg and the mean OPA was 3.4 mmHg. After one month using Travoprost 0.004% the mean IOP with GAT was 15.4 mmHg (p<0.001), with PDCT was 17.3 mmHg (p<0.001), and the mean OPA was 2.7 mmHg (p<0.001).

Conclusions:: OPA was significantly lower as well as the IOP after use Travoprost 0.004% for on month. PDCT may be a useful device for further studies involving OPA.

Keywords: drug toxicity/drug effects • intraocular pressure 
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