May 2007
Volume 48, Issue 13
ARVO Annual Meeting Abstract  |   May 2007
Comparison of Class of Pre-Procedure Glaucoma Monotherapy and Effectiveness of Selective Laser Trabeculoplasty
Author Affiliations & Notes
  • L. F. Jindra
    Ophthalmology, Columbia University, Floral Park, New York
    Ophthalmology, Winthrop University Hospital, Mineola, New York
  • A. Gupta
    Transitional, New York Hospital Queens, Flushing, New York
  • E. M. Miglino
    Floral Park Ophthalmology, Floral Park, New York
  • Footnotes
    Commercial Relationships L.F. Jindra, None; A. Gupta, None; E.M. Miglino, None.
  • Footnotes
    Support None.
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 3983. doi:
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      L. F. Jindra, A. Gupta, E. M. Miglino; Comparison of Class of Pre-Procedure Glaucoma Monotherapy and Effectiveness of Selective Laser Trabeculoplasty. Invest. Ophthalmol. Vis. Sci. 2007;48(13):3983.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose:: To compare the effectiveness of Selective Laser Trabeculoplasty (SLT), in decreasing intraocular pressure (IOP), among patients on four classes of pre-procedure glaucoma monotherapy: prostaglandin (PG), beta-blocker (BB), carbonic anhydrase inhibitor (CAI), or alpha-agonist (AA).

Methods:: A retrospective chart review was performed on 203 eyes out of 1566 eyes, from a consecutive case series of patients treated with SLT over 4 years. ANOVA testing was used to evaluate the mean decrease in IOP among the four groups.

Results:: After SLT, relative mean decrease in IOP was: 26% and 32% for PG and non-PG; 27% and 23% for BB and non-BB; 38% and 20% for CAI and non-CAI, and 37% and 21% for AA and non-AA. Results were significant with p<0.001.

Conclusions:: In this series of patients on pre-procedure glaucoma monotherapy, the effectiveness of SLT to decrease IOP was: greatest with carbonic anhydrase inhibitor or alpha-agonist, followed by beta-blocker, and least with prostaglandin. Further study is required to evaluate higher order interactions seen in combination therapy.

Keywords: clinical (human) or epidemiologic studies: biostatistics/epidemiology methodology • laser • trabecular meshwork 

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