Abstract
Purpose::
To evaluate the long-term course of visual field defects after intravitreous administration of indocyanine green in macular hole surgery.
Methods::
Seven eyes of 7 patients with visual field defects after adjunctive use of indocyanine green in macular hole surgery between February 2001 and January 2002 were enrolled. Humphrey static perimetry and best-corrected visual acuity were examined periodically. The main outcome measure was mean deviation (MD) of Humphrey (30-2) SITA-fast program.
Results::
All patients were followed up for more than 3 years. Preoperative MD was -3.5±3.1 dB (mean±standard deviation [SD]). Postoperative MD was -13.3±4.9 dB at 1 year, -13.4±4.6 dB at 2 years, -16.2±5.1 dB at 3 years. A statistically significant decrease of mean MD was found between 1 year and 3 years after surgery (p<0.05). Fundus examination of the patients with postoperative decreasing of MD showed a pale optic disc. There was no significant difference in postoperative best-corrected visual acuity at any time.
Conclusions::
The visual field defect after the use of indocyanine green in macular hole surgery may keep worsening for several years. Indocyanine green associated visual field defect needs long-term follow-up.
Keywords: drug toxicity/drug effects • macular holes • visual fields