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M. Ferencz, Z. Szepessy, G. M. Somfai, I. Kovács, B. Entz, Z. Récsán, G. Salacz; Posterior Capsule Opacification and Anatomical Success in Combined Operations for Macular Holes. Invest. Ophthalmol. Vis. Sci. 2007;48(13):4127.
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The anatomical success and the amount of posterior capsule opacification (PCO) was studied in patients with idiopathic macular holes (MH) undergoing combined operation of phacoemulsification with PCL implantation and pars plana vitrectomy.
Combined surgery was performed in 23 eyes (Group A), followed by 16% C3F8 gas tamponade of the vitreous body. In the control group of 39 eyes with MH (Group B) phacoemulsification was not performed, while in another set of 18 eyes with epiretinal membrane (Group C), combined surgery was performed without gas insufflation. The anatomical success of the operation was studied by a Zeiss Stratus OCT device 12±2 months postoperatively. The amount of PCO was measured with the EPCO program.
In Group A the macular hole has closed only in 6 patients (26%) which was significantly lower than the closure rate achieved in the control B group (36/39, 92%, p<.001). In Group A PCO occurred in 12 patients (52%) after operation, clinically significant PCO was only found in patients with persistent MH. Epiretinal membrane removal with combined surgery without intravitreal gas injection (Group C) resulted in lower PCO rate (2/18, 11%, p<.001).
The reason of persistent MH might be the result of more pronounced postoperative inflammation due to combined surgery. According to our results intraoperative gas injection can be a trigger in PCO development.
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