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M. A. Gamulescu, A. F. Walter, H. Sachs, H. Helbig; Functional and Morphological Results After Bevacizumab (Avastin®) Treatment of Idiopathic Juxtafoveal Retinal Telangietasis. Invest. Ophthalmol. Vis. Sci. 2007;48(13):4160.
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Idiopathic juxtafoveal retinal telangiectasis (JRT) are a rare cause of visual impairement in the middle-aged population. First described by Gass, they comprise a diverse group of capillary changes in foveal and parafoveal areas and can be divided into three distinct types with different features in fluorescein angiography (FA) and optical coherence tomography (OCT). Treatment options are scarce and mostly confined to unilateral type I JRT. The purpose of this work was to describe functional and morphological outcome of patients treated with intravitreal bevacizumab.
Retrospective case series of three male patients with JRT. After informed consent, all patients received intravitreal bevacizumab 1,0mg/0,1ml. One patient had unilateral JRT (type I) and was treated once, while two patients had bilateral JRT (type II) and were treated thrice on a monthly basis. Follow-up was 4 months in all patients and comprised BCVA, ophthalmologic examination, FA and OCT.
Single intravitreal bevacizumab injection resulted in a marked increase in BCVA from 20/50 to 20/20 during the first 4 weeks after injection in the patient with type I JRT. This was sustained over the next 3 months of follow-up. Leakage on FA and macular oedema on OCT decreased significantly. In contrast, in the patients with type II JRT, leakage on FA decreased likewise, but this was not accompanied by an increase in BCVA despite triple injections. Small cystic changes seen on OCT remained unchanged.
Patients with type I JRT with pronounced macular oedema on OCT may benefit from intravitreal bevacizumab injections showing functional as well as morphological improvement, while patients with type II JRT with minimal cystic changes on OCT do not show functional improvement.
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