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Y.-F. Ng, H. Chan, P. Chu, B. Beale, B. Gilger, F. Wong; Retinal Origins and Nonlinear Characteristics of the Porcine Multifocal Erg. Invest. Ophthalmol. Vis. Sci. 2007;48(13):4181.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate the cellular contributions and nonlinearity of the porcine multifocal ERG (mfERG), which are essential for comparing and extrapolating the experimental results from porcines to those of primates.
Photopic mfERGs were recorded from six anesthetized porcines using a 103-hexagon stimulus. The mfERGs were obtained before and after the administration of isoflurane (ISO), N-methyl-D-asparatic acid (NMDA), tetrodotoxin (TTX), 2-amino-4-phosphonobutyric acid (APB) and cis-2,3-piperidinedicarboylic acid (PDA) to identify contributions to the mfERG from inner retinal neurons, the ON-pathway and the OFF-pathway, respectively.
The first-order mfERG response (K1) from the porcine eye under the influence of different pharmacologic agents were similar to those reported in the previous studies. We found that the NMDA altered the retinal adaptive characteristic in the second-order mfERG response (K2.1). The ON- and OFF-pathways have some indirect contributions to K2.1.
The K2.1 traces after PDA injection were similar in shape of those after NMDA application and these two conditions may involve common cellular contributions.
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