May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Retinal Origins and Nonlinear Characteristics of the Porcine Multifocal Erg
Y.-F. Ng; H. Chan; P. Chu; B. Beale; B. Gilger; F. Wong
Author Affiliations & Notes
  • Y.-F. Ng
    School of Optometry, Hong Kong Polytechnic University, Hong Kong, Hong Kong
  • H. Chan
    School of Optometry, Hong Kong Polytechnic University, Hong Kong, Hong Kong
  • P. Chu
    School of Optometry, Hong Kong Polytechnic University, Hong Kong, Hong Kong
  • B. Beale
    Ophthalmology Service, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina
  • B. Gilger
    Ophthalmology Service, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina
  • F. Wong
    Department of Ophthalmology, School of Medicine, Duke University, Durham, North Carolina
  • Footnotes
    Commercial Relationships Y. Ng, None; H. Chan, None; P. Chu, None; B. Beale, None; B. Gilger, None; F. Wong, None.
  • Footnotes
    Support Associated Fund (Research Postgraduate) PolyU, Internal Competitive Research Grant (A-PG-73) PolyU, Competitive Earmark Research Grant (PolyU 5415/06M) RGC, HK
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 4181. doi:
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      Y.-F. Ng, H. Chan, P. Chu, B. Beale, B. Gilger, F. Wong; Retinal Origins and Nonlinear Characteristics of the Porcine Multifocal Erg. Invest. Ophthalmol. Vis. Sci. 2007;48(13):4181.

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Abstract

Purpose:: To investigate the cellular contributions and nonlinearity of the porcine multifocal ERG (mfERG), which are essential for comparing and extrapolating the experimental results from porcines to those of primates.

Methods:: Photopic mfERGs were recorded from six anesthetized porcines using a 103-hexagon stimulus. The mfERGs were obtained before and after the administration of isoflurane (ISO), N-methyl-D-asparatic acid (NMDA), tetrodotoxin (TTX), 2-amino-4-phosphonobutyric acid (APB) and cis-2,3-piperidinedicarboylic acid (PDA) to identify contributions to the mfERG from inner retinal neurons, the ON-pathway and the OFF-pathway, respectively.

Results:: The first-order mfERG response (K1) from the porcine eye under the influence of different pharmacologic agents were similar to those reported in the previous studies. We found that the NMDA altered the retinal adaptive characteristic in the second-order mfERG response (K2.1). The ON- and OFF-pathways have some indirect contributions to K2.1.

Conclusions:: The K2.1 traces after PDA injection were similar in shape of those after NMDA application and these two conditions may involve common cellular contributions.

Keywords: electroretinography: non-clinical • retina • retinal connections, networks, circuitry 
© 2007, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
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