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H. Kim, A. Choi, J.-S. Choi, K.-A. Kim, C.-K. Joo; Kr-31378, A KAtp Channel Opener, Induces the Protection of Retinal Ganglion Cells in Two Retinal Ischemic Models. Invest. Ophthalmol. Vis. Sci. 2007;48(13):4195.
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To protect retinal ganglion cells (RGC) on retinal ischemic injury, the effect of KR-31378 was studied in rat eyes suffering from experimentally-induced retinal ischemia.
The retinal ischemia was induced by high intra ocular pressure for acute ischemia and three episcleral vein occlusion for chronic retinal ischemia. KR-31378 was given orally in three different doses. The retinal ganglion cells were observed by retrograde labeling.
In acute retinal ischemic model, KR-31378 protected the degeneration of retinal neurons, dose dependently. In chronic ischemia, RGC density in KR-31378 treated group was statistically higher than the non-treated group and also reduced intra ocular pressure (IOP).
These findings indicate that systemic KR-31378 may protect an ischemic injury induced ganglion cell loss in glaucoma
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