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R. D. Ferguson, N. V. Iftimia, D. X. Hammer, S. A. Burns; Depth-Resolved Tracking Doppler Flowmetry. Invest. Ophthalmol. Vis. Sci. 2007;48(13):4254.
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© ARVO (1962-2015); The Authors (2016-present)
To combine new and existing retinal imaging technologies to yield dye-free, functional imaging capabilities for ocular blood flow. Novel methods for capturing depth-resolved Tracking Doppler Flowmetry (TDF) blood flow images are presented.
By stabilizing a slowly scanning laser line on the retina imaged confocally to a linear detector array, wide field Doppler power spectral imaging was demonstrated in which each image pixel is sampled thousands of times at up to 50KHz. Doppler power images are interpreted as retinal flow. TDF is sensitive to transverse (in retinal plane) velocity components, but with poor axial localization of flow. Fourier domain methods, such as swept-source OCT (SSOCT), provide rapid retinal imaging capabilities with high axial resolution and sensitivity to axial flow velocity components. By blending these strengths in a new optical design, TDF blood flow imaging is significantly enhanced and acquires useful axial resolution. A new apparatus combining TDF and swept-source illumination is described.
New algorithms for time-phase analysis in swept-source sub-bands are demonstrated and preliminary images are presented. The system trade spaces of axial resolution and velocity sensitivity for "intermediated coherence" dye-free angiography are discussed .
TDF/SSODT is a promising technique which provides an ‘angographic view" with depth resolution intermediate between SLO and OCT methods.
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