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T. Iwasaki, M. Miura, M. Yamanari, Y. Watabnabe, H. Mori, A. E. Elsner, K. Kawana, T. Oshika, T. Yatagai, Y. Yasuno; Imaging Polarimetry in Anterior Segment Disorders With Polarization-Sensitive Fourier-Domain Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2007;48(13):4255.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the polarization properties of anterior segment disorders in vivo using polarization-sensitive Fourier-domain optical coherence tomography (PS-FD-OCT).
We prospectively examined one case of the normal eye, one case of necrotizing scleritis, two cases with blebs following glaucoma filtering surgery, and one case of granular corneal dystrophy. We developed a fiber-based PS-FD-OCT system to image the anterior segment. The light source was a superluminescent diode with a central wavelength of 840 nm. The axial resolution was 8.3 microns in the air. Two synchronized line-CCD cameras allowed high-speed measurement of birefringence of retina (line rate 27.7 kHz). Phase retardation and orientation of the birefringence were measured with a Jones matrix based algorism, and the phase retardation map of the eye was visualized as depth-resolved image in addition to the conventional cross sectional OCT image. Fiber birefringence of the OCT system was canceled using Jones matrix at the surface of the eye.
In the polarization image of the normal eye, striking polarization changes were observed at the sclera. In the eyes with neocrotizing scleritis, abnormal thinning of the sclera was seen. In the eyes after filtering glaucoma surgery, a polarization change in the conjunctiva due to the abnormal fibrosis after surgery was observed.
PS-FD-OCT is an effective tool to understand the polarization properties of different types of pathological changes in the anterior segment of the eye.
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