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M. C. Grieshaber, R. Katamay, K. Gugleta, J. Flammer, S. Orgül; Relationship Between Ocular Pulse Amplitude and Systemic Blood Pressure Measurements. Invest. Ophthalmol. Vis. Sci. 2007;48(13):4384.
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To determine whether ocular pulse amplitude (OPA) measured with dynamic contour tonometry is related to systemic blood pressure parameters.
Blood pressure was measured continuously and simultaneously with OPA in one randomly selected eye of 29 healthy subjects. Systemic parameters of interest were: systolic and diastolic blood pressure and their difference (blood pressure amplitude), as well as left ventricle ejection time (LVET) defined as time between diastolic trough and systolic peak. In addition, an axial length (AL) of the eye was measured. Association between OPA, AL and systemic cardiovascular parameters was analyzed in a multivariate regression model.
The OPA readings were not related to the systolic (p= 0.36), diastolic (p = 0.58) blood pressure nor to the blood pressure amplitude (p=0.34). However, they were significantly influenced by LVET (t = 3.446, p= 0.002), IOP (t = 3.32; p = 0.003), and axial length (t = -2.87; p = 0.011) but not by age (p = 0.14).
The OPA readings measured with dynamic contour tonometry in healthy subjects are not influenced by the blood pressure and its amplitude, probably due to regulatory mechanisms in the carotid artery. It seems however that the OPA rather depends on the time course of the cardiac contraction.
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