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B. Brankin, M. Campbell, M. Humphries, P. Kenna, P. Humphries; Investigation of ZO-1/beta Catenin and P120-Catenin Expression at the Outer Limiting Membrane in Retinal Degenerations. Invest. Ophthalmol. Vis. Sci. 2007;48(13):4497.
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The purpose of this work was to investigate the time course of expression of ZO-1, beta-catenin and p102-catenin in the developing retina of Rho(-/-) and wild type mice.
Confocal microscopy and co-immunoprecipitation methods were used.
ZO-1 expression was compromised at the outer limiting membrane in Rho(-/-) mouse retina at 3 weeks old compared to wild type controls. Levels of beta catenin and p120-catenin expression decreased at 3 weeks and at 4 weeks respectively. Association between ZO-1 and E-cadherin was maximal at 2-3 weeks.
Adherens junction proteins at the outer limiting membrane are altered in Rho(-/-) mice. The interaction of ZO-1, p120-catenin and beta-catenin may be important in order to stabilise the outer limiting membrane and for normal photoreceptor function.
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