May 2007
Volume 48, Issue 13
ARVO Annual Meeting Abstract  |   May 2007
Combination Therapy for Choroidal Neovascularzation
Author Affiliations & Notes
  • N. M. Jabbour
    Ophthalmology, West Virginia University / Mid Atlantic Retina Consultations, Morgantown, West Virginia
  • Footnotes
    Commercial Relationships N.M. Jabbour, None.
  • Footnotes
    Support M.A.R.C.-1155
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 4554. doi:
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    • Get Citation

      N. M. Jabbour; Combination Therapy for Choroidal Neovascularzation. Invest. Ophthalmol. Vis. Sci. 2007;48(13):4554.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose:: To evaluate the anatomic and visual outcomes following combination photodynamic therapy (PDT) and intravitreal Avastin (IVA) for treating choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD).

Methods:: Twenty-seven (27) consecutive eyes with active CNV (all lesions) were treated with PDT followed by IVA 7 to 14 days later. Fluorescein angiography (FA) and optical coherence tomography (OCT) were performed every 3 weeks for a minimum of 3 months. Re-treatment with PDT or IVA was done based on predetermined recurrence criteria.

Results:: After an average follow-up period of 6 months (3-12 months) Snellen visual acuity improved by an average of 2.2 lines (1-7 lines) in 67% of cases, 15% worsened by 1 line and 18% did not change. 56% of cases did not require any additional treatment, 18% required 2 additional treatments (average of 3 months between treatments), 7.4% and 3.7% required 3 and 4 additional treatments, respectively .

Conclusions:: Combination PDT and IVA treatment resulted in improved vision and decreased frequency of treatment in eyes with CNV secondary to AMD.

Keywords: age-related macular degeneration • photodynamic therapy • growth factors/growth factor receptors 

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