May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Treatment of Retinal Pigment Epithelium Detachment Associated With Age-Related Macular Degeneration With Bevacizumab or Combination Photodynamic Therapy/ Intravitreous Triamcinolone Acetonide
R. Singh; P. E. Carvounis; J. Heffez; A. Kopel; E. Holz
Author Affiliations & Notes
  • R. Singh
    Cullen Eye Institute, Baylor College of Medicine, Houston, Texas
  • P. E. Carvounis
    Cullen Eye Institute, Baylor College of Medicine, Houston, Texas
  • J. Heffez
    Department of Ophthalmology, Tulane University, New Orleans, Louisiana
  • A. Kopel
    Cullen Eye Institute, Baylor College of Medicine, Houston, Texas
  • E. Holz
    Cullen Eye Institute, Baylor College of Medicine, Houston, Texas
  • Footnotes
    Commercial Relationships R. Singh, None; P.E. Carvounis, None; J. Heffez, None; A. Kopel, None; E. Holz, None.
  • Footnotes
    Support None.
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 4558. doi:
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      R. Singh, P. E. Carvounis, J. Heffez, A. Kopel, E. Holz; Treatment of Retinal Pigment Epithelium Detachment Associated With Age-Related Macular Degeneration With Bevacizumab or Combination Photodynamic Therapy/ Intravitreous Triamcinolone Acetonide. Invest. Ophthalmol. Vis. Sci. 2007;48(13):4558.

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Abstract

Purpose:: To compare intravitreous bevacizumab (AVA) to photodynamic therapy and intravitreous triamcinolone (PDT+IVTK), for the treatment of pigment epithelial detachments (PEDs) associated with age-related macular degeneration (ARMD).

Methods:: Retrospective comparative study of 21 eyes of 21 consecutive patients with ARMD-associated PEDs, initial visual acuity better than 20/200, treated with one or more sessions of AVA (9 eyes of 9 patients) or PDT+IVTK (12 eyes of 12 patients)

Results:: Baseline logMAR visual acuity was similar in the two groups (AVA group: 0.53 (20/67), PDT+IVTK group: 0.48 (20/61), p=0.73). At 6 months, logMAR visual acuity was significantly better in the AVA group compared to the PDT+IVTK group (AVA group: 0.34 (20/44), PDT+IVTK group: 0.70 (20/100), p=0.007). The majority of PEDs persisted (AVA group: 5/9, PDT+IVTK group: 5/12, p=0.41) whereas 3/12 eyes treated with PDT+IVTK developed a RPE tear (compared to none in the AVA group, p=0.22).

Conclusions:: Treatment of PEDs associated with ARMD with bevacizumab may result in superior visual outcomes compared to treatment with combination photodynamic therapy/intravitreous triamcinolone acetonide.

Keywords: age-related macular degeneration • photodynamic therapy • retinal pigment epithelium 
© 2007, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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