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T. Yamaguchi, N. Ishida, A. Yasuda, A. Kogure, F. M. Polack; Comparison of Incidence of Neovascularization Between Interrupted Suture and Continuous Suture After Penetrating Keratoplasty. Invest. Ophthalmol. Vis. Sci. 2007;48(13):4679.
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© ARVO (1962-2015); The Authors (2016-present)
To compare the incidence of neovascularization between interrupted sutures (IRS) and continuous sutures (CTS) after penetrating keratoplasty (PKP).
Twenty six eyes of 26 cases underwent PKP were analyzed. Mean age of the patients was 65 years old (46-89). Thirteen patients were male and 13 patients were female. Seventeen cases of bullous keratopathy, 5 cases of keratoconus and 2 cases of corneal dystrophy (lattice dystrophy:1, Macular dystrophy:1) were studied. Suturing Methods:8 interrupted sutures with 16 bites continuous sutures using 10-0 nylon were made. Suture knots of 8 IRS were set on the surface of host cornea and suture knot of CTS were buried host-graft junction at 12:30 position. None of the corneas had any vessels preoperatively. The number of suture with neovascularization was observed and counted using slit-lamp at the time when the vessels were most active condition from 19 to 131 days after PKP.
Average number of suture with neovascularization were 4.65 per 8 IRS and 3.65 sutures with neovascularization per 16 bites CTS. There was statistically significant difference in the rate of neovascularized sutures between IRS and CTS (p<0.01). Graft rejection was found in 2 eyes (7.7%).
Interrupted suture produces vascularization at the site of the knot. This does not occur with continous suture. Suture knot stimulates the grouwth of new vessels.
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