Comparative Efficacy of Intracameral Antibiotics versus Drug Delivery Intraocular Lens in Endophthalmitis Rabbit Model

Abstract

 

Purpose:

 

To evaluate the in vivo efficacy of intracameral gatifloxacin(GFLX) 0.5% versus drug delivery intraocular lens (D.D.IOL)in the treatment of Enterococcus faecalis endophthalmitis inrabbits.

 

Methods:

 

Experimental endophthalmitis was induced in rabbits by intracameraladministration of E.faecalis KOS1 at the end of cataract surgerywith IOL implantation (10⁶ CFU/eye). E. faecalis strain, KOS1(clinical isolate from endophthalmitis case) were used. IntracameralGFLX 0.5% were administered at the end of surgery (immediatelypostinfection). Silicone IOLs were used for intracameral antibioticsgroup. D.D.IOLs, antibiotics-treated hydrogel lenses, were immersedin GFLX 0.5%. Those eyes were enucleated at 24 hr, 48 hr and72 hr postinfection. Bacterial population within those eyeswas examined. Aqueous concentrations for GFLX were detectedin both groups using by HPLC.

 

Results:

 

Tables showed the bacterial populations in eyes , and aqueousconcentrations for GFLX through 72 hr. Both intracameral GFLXgroup and D.D.IOL group performed significantly better thancontrol in the treatment of endophthalmitis (P<0.01). Therewere no differences between those 2 groups. Aqueous concentrationsin intracameral GFLX group were higher than those in D.D.IOLgroup at 4 hr and 8 hr after surgery. However, at 24 hr, therewere no differences between these 2 groups.

 

Conclusions:

 

Intracameral GFLX 0.5% and D.D.IOL (adsorbed GFLX 0.5%) havesimilar efficacy in the treatment of E. faecalis endophthalmitisin rabbits. 

 

 

Keywords: endophthalmitis • intraocular lens • antibiotics/antifungals/antiparasitics