May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
True Cavitations in Uveal Melanoma: Apoptotic Genesis
Author Affiliations & Notes
  • D. E. Pelayes
    Ophthalmology, Buenos Aires University, Buenos Aires, Argentina
    Pathology, Laboratory Investigation Ophthalmologic and Visual Science (LIOCiV), Buenos Aires University, Argentina
  • D. Colombero
    Ophthalmology, Buenos Aires University, Buenos Aires, Argentina
    Pathology, Laboratory Investigation Ophthalmologic and Visual Science (LIOCiV), Buenos Aires University, Argentina
  • C. H. Pastore
    Pathology, Laboratory Investigation Ophthalmologic and Visual Science (LIOCiV), Buenos Aires University, Argentina
  • N. Lago
    Pathology, Laboratory Investigation Ophthalmologic and Visual Science (LIOCiV), Buenos Aires University, Argentina
  • L. Racca
    Pathology, Laboratory Investigation Ophthalmologic and Visual Science (LIOCiV), Buenos Aires University, Argentina
  • R. Ronchetti
    Pathology, Laboratory Investigation Ophthalmologic and Visual Science (LIOCiV), Buenos Aires University, Argentina
  • S. Presmanes
    Pathology, Laboratory Investigation Ophthalmologic and Visual Science (LIOCiV), Buenos Aires University, Argentina
  • J. O. Zarate
    Pathology, Laboratory Investigation Ophthalmologic and Visual Science (LIOCiV), Buenos Aires University, Argentina
  • Footnotes
    Commercial Relationships D.E. Pelayes, None; D. Colombero, None; C.H. Pastore, None; N. Lago, None; L. Racca, None; R. Ronchetti, None; S. Presmanes, None; J.O. Zarate, None.
  • Footnotes
    Support None.
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 4781. doi:
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    • Get Citation

      D. E. Pelayes, D. Colombero, C. H. Pastore, N. Lago, L. Racca, R. Ronchetti, S. Presmanes, J. O. Zarate; True Cavitations in Uveal Melanoma: Apoptotic Genesis. Invest. Ophthalmol. Vis. Sci. 2007;48(13):4781.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose:: To report the histopathology of true Cavitary Melanoma and to describe the apoptotic mechanism of these cavitations.

Methods:: Three surgical cases of melanoma were included: one of the ciliary body and choroid, obtained by iridiociclectomy and two of the ciliary body obtained by enucleation. The samples were studied with hematoxylin & eosin, S-100, HMB-45, Anexine-V and electronic microscopy.

Results:: All cases showed epitheloid and fusiform cells, with different cavitary sectors, and the presences of degenerative cells. The three specimens were positive for S-100 and HMB-45. An apoptotic mechanism was found in different stages by electronic microscopy and Annexin-V inmunomarcation. All cases remained free of metastasis or local invasion within 5.5 years of median follow-up.

Conclusions:: : The cavitary melanomas are rare variants of uveal melanoma. None of the cases reported previously explain the biological and clinical importance of the cavitation process. The present cases show that the process of cavitation is mainly mediated by apoptotic mechanism, and it could be a favorable prognostic factor.

Keywords: melanoma • apoptosis/cell death • oncology 
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