Abstract
Purpose::
To evaluate the potential benefits in functional/structural outcomes of sequential intravitreal Triamcinolone Acetonide (IVTA)/grid photocoagulation (GP) for diabetic macular edema (DME).
Methods::
Fourteen insulin-dependent diabetic patients were randomly assigned to one of the following treatments. 1. IVTA followed after 4 weeks by a standard GP (n = 7). 2. Standard GP (n =7). For each patient, EDTRS acuity, microperimetry (Nikon MP1), focal ERGs and macular structure by OCT3, were measured in a blinded fashion at baseline and 3 months post-treatment.
Results::
At 3 months, EDTRS acuity improved (p < 0.05) in both groups compared to baseline values (average increase 14 and 15 letters, respectively). In group 1, but not in group 2 patients, FERG amplitude and MP1 sensitivity improved (p < 0.05) compared to baseline values. Macular thickness decreased (p < 0.01) from baseline in both groups (on average by 340 and 220 microns, respectively, between-group difference, p: ns).
Conclusions::
Sequential IVTA/GP for DME may provide some benefits as revelaed by macular cone functional assays, suggesting an anti-flogistic protective role of IVTA on neuro-retinal neurons.
Keywords: diabetic retinopathy • laser • electrophysiology: clinical