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M. Streho, I. Ingster-Moati, L. Haddad, L. Tepenier, A. P. Brezin, D. Monnet; Multifocal Electroretinogram Findings and Comparison With OCT Results in a Study of 87 Patients With Birdshot Chorioretinopathy. Invest. Ophthalmol. Vis. Sci. 2007;48(13):5164.
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© ARVO (1962-2015); The Authors (2016-present)
To describe multifocal electroretinogram (mfERG) features, and their relationship to optical coherence tomography (OCT) results in a cohort of 87 patients with birdshot chorioretinopathy (BCR).
In a single-center, cross sectional study, 87 HLA-A-29-positive patients with BCR underwent a standardized examination including mfERG and OCT, in the same order, on a single day, in November 2005. Multifocal ERG was obtained following ISCEV recommendations using 61 retinally scaled hexagons. The N1 (first negative trough) and P1 (first positive peak) components of the first order kernel response of the mfERG were measured on the central 2, 5 and 10 degrees and compared with macular thickness and volume on the OCT.
There were 35 males and 52 females and the mean age was 56,4 years [24-81] .The mean duration of the disease was 5,4 years [0,1-33,5]. The N1 and P1 components on the central 2° were significantly correlated with the best-corrected visual acuity (p<0.001). The N1 implicit time on 2° and 5° was significantly correlated with the macular thickness on the OCT (N1/2°, R=0,23 , p=0,004; N1/5°, R=0,24 , p<0,001). The N1 implicit time on 10° was also significantly correlated with the macular volume on the OCT (N1/10° , R=0,24 , p=0,002). However, there were no significant correlation between N1 amplitude on 2° and 5° (N1/2° R=-0,08 , p=0,31 ; N1/5° R=0,01 , p=0,94), P1 amplitude on 2° and 5° (P1/2° R=-0,15 , p=0,07 ; P1/5° R=-0,02 , p=0,78), P1 implicit time on 2° and 5° (P1/2° R=0,04 , p=0,64 ; P1/5° R=0,01 , p=0,94) and macular thickness on the OCT. There were no significant correlation between N1 amplitude on 10° (N1/2° R=0,17 , p=0,027), P1 amplitude on 10° (P1/10° R=0,12 , p=0,11), P1 implicit time on 10° (P1/10° R=0,11 , p=0,16) and macular volume on the OCT.
BCR has not previously been studied with multifocal ERG. This study provides a mfERG database for 87 patients with BCR. There is a significant correlation between the N1 implicit time for all the degrees and the macular thickness and volume on the OCT. However there is no significant correlation between the P1 components for all the degrees and the macular thickness and volume on the OCT. These findings suggest that the N1 implicit time is the most reliable mfERG indicator in the birdshot chorioretinopathy. These results are in accordance to previously published global ERG studies, showing the cone b-wave flicker implicit time to be the most reliable parameter for the follow up of patients.
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