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J. D. Luna Pinto, J. C. Muiño, M. Romero, M. Ferrero, G. Ravinovich, C. P. Juarez; Anti-Galectin-1 Antibodies in Patients With Pars Planitis. Invest. Ophthalmol. Vis. Sci. 2007;48(13):5186.
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© ARVO (1962-2015); The Authors (2016-present)
Galectin - 1 (Gal -1), an endogenous galectin play a critical role in regulation of the immune response. We have previously demonstrated the presence of anti-gal-1 antibodies in patients with uveitis (ARVO, 2006). We know evaluate the presence of these auto-antibodies in patients with pars planitis.
17 patients with clinically diagnosed pars planitis, has been prospectively followed, from our uveitis clinic over the past 5 years, for the presence of specific IgG, IgA and IgE anti-gal-1 antibodies, by ELISA and compared with healthy control subjects (n: 14). The patients were classified according to clinical criteria and to the response to treatment in good (n: 13) and poor (n: 3) prognosis.
IgG and IgE anti Gal-1 only, or overlapped were increased in sera from patients with Pars Planitis and bad prognosis (n: 3) and the presence of specific IgA to Gal - 1 only (n: 1) or overlapped with IgG and IgE anti Gal - 1 (n: 12) presented good evolution (n: 13) (p<0.001). One case with moderate vision impairment did have IgG, IgA, IgE anti Gal - 1.
The results presented here suggest the importance of specific IgG and IgE anti Gal - 1 in Pars Planitis with poor prognosis, as well as the presence of IgA anti Gal - 1 associated with good prognosis.
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