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P. E. Liggett, J. M. Colina-Luquez, A. Lavaque, G. Haffner, N. A. Chaudhry; Combined Simultaneous Transpupillary Thermotherapy and Icg-based Photodynamic Therapy for Choroidal Melanoma - Three Years Report. Invest. Ophthalmol. Vis. Sci. 2007;48(13):5229.
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To report the results of the combination therapy of simultaneous hyperthermia by transpupillary thermotherapy and indocyanine green-based photodynamic therapy is an effective treatment for small and medium choroidal melanomas.
Thirty three patients with small and medium choroidal melanomas were treated with combined simultaneous transpupillary thermotherapy and indocyanine green-based photodynamic therapy.
The median age of the 33 patients was 64 years (range 35 to 88 years). The pretreatment volume of the tumors ranged from 13.6 to 764.5 mm3 (mean, 123.6 +/- 106.2 mm3). After a mean of 2.1 treatments (range, 1 to 5 treatments), 70% of the tumors showed a significant volume reduction, 30% of the tumors showed stabilization in size, all of them without clinical evidence of recurrences. The follow-up ranged from 7 to 75 months (mean, 36 +/- 19 months). Complications included retinal vascular occlusions, edema and superficial scarring of the macula, and rhegmatogenous retinal detachment.
The effects of combined simultaneous transpupillary thermotherapy and indocyanine green-based photodynamic therapy appears to be effective in achieving local tumor control in selected small and medium choroidal melanomas.
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