May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Radioactive Plaque Brachytherapy for Iris and Iridociliary Melanoma: High-Frequency Ultrasound Findings Before and in Response to Treatment
Author Affiliations & Notes
  • S. Reddy
    The New York Eye Cancer Center, New York, New York
    New York University School of Medicine, New York, New York
  • K. Chin
    The New York Eye Cancer Center, New York, New York
  • P. T. Finger
    The New York Eye Cancer Center, New York, New York
    The New York Eye and Ear Infirmary, New York, New York
  • Footnotes
    Commercial Relationships S. Reddy, None; K. Chin, None; P.T. Finger, None.
  • Footnotes
    Support The EyeCare Foundation, Inc., New York City, NY, USA http://eyecarefoundation.org
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 5256. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      S. Reddy, K. Chin, P. T. Finger; Radioactive Plaque Brachytherapy for Iris and Iridociliary Melanoma: High-Frequency Ultrasound Findings Before and in Response to Treatment. Invest. Ophthalmol. Vis. Sci. 2007;48(13):5256.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose:: To evaluate high frequency ultrasonographic characteristics such as size, and regression of iris and iridociliary melanomas before and after plaque brachytherapy.

Methods:: A retrospective review of high-frequency ultrasound characteristics in 24 consecutive iris and iridociliary melanomas prior to and after radiation therapy (e.g. tumor thickness, internal reflectivity, shape, effect on insertion of the iris root, and extension into adjacent normal tissues).

Results:: Median tumor thickness prior to therapy was 2.3 mm (range 1.4 to 4.3). Eleven (45.8%) iris melanomas were club-shaped, 19 (79.2%) involved the ciliary body, 4 (16.7%) caused disinsertion of the iris root, and 18 (75%) involved the iris pigment epithelium. At a median follow-up of 30 months after plaque brachytherapy, the median tumor thickness diminished to 1.2 mm (mean 1.15, range 0.85 to 2.1 mm). While all tumors exhibited a reduction in thickness, no tumors showed additional regression after 30 months past treatment. Fourteen (58.3%) were noted to increase in internal reflectivity. There was one failure of local control (at 6 years), successfully treated with a second application of plaque radiation therapy.

Conclusions:: High frequency ultrasound is helpful to identify diagnostic characteristics of iris and iridociliary melanomas and to quantify tumor size and response to radiation.

Keywords: melanoma • iris • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×