The Use of Intra Operatorial Avastin as Coadjutant in the Surgical Treatment of Recurrence Pterygium

Abstract

 

Purpose:

 

To evaluate the effectiveness of the intra-operative use ofavastin in the surgical treatment of the recurrence pterygium.

 

Methods:

 

A prospective study was accomplished, experimental of 58 patient(58 eyes) with recurrence pterygium submitted to surgical treatmentin the period of October from 2005 to March of 2006. The patientshad a six-month follow-up period. 32 patients (55,2%) were male,26 female (44,8%) and the average age was 35 years (24 to 46years old). Two groups were chosen at random by table of aleatorydigits: test group (31 eyes) - autologus conjunctive transplants+ intra-operative Avastin use of 0,3 ml subconjunctive, controlgroup (27 eyes) - autologus conjunctive transplants. This experimentwas approved by the Committee of Ethics in Research (CEP) ofthe Federal University of the Triângulo Mineiro - Brazil.

 

Results:

 

In the test group, 6 recurrence cases were observed (19,3%),whereas in the control group the recurrence happened to 5 patients(18,5%). The recurrence was observed between the thirtieth andninetieth post operatory period. Mild keratitis and ocular hypertension(PIO between 21 and 23 mmHg) were considered as possible complicationsof Avastin use in five patients. The statistic analysis wasdone by the qui-square test, where ρ>0,05 showed no statisticsignificance between the two groups.

 

Conclusions:

 

According to the obtained results, it can be concluded thatthe use of Avastin in recurrence pterygium treatment has nopositive influence in its recurrence. 

 

 

Clinical Trial:

 

CEP:091/2002-UFTM-MG-Brazil

 

Keywords: Pterygium • conjunctiva • cornea: clinical science