May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Effect of Topical Mitomycin C on Ciliary Body and Intraocular Pressure After Photorefractive Keratectomy: An Experimental Study
G. D. Kymionis; V. Diakonis; S. Charisis; N. Tsiklis; D. Bouzoukis; A. Pallikaris; I. Naoumidi; M. Tsilimbaris
Author Affiliations & Notes
  • G. D. Kymionis
    Dep. of Opthalmology, Institute of Vision, Un Cret, University of Crete, Heraklion, Greece
  • V. Diakonis
    Dep. of Opthalmology, Institute of Vision, Un Cret, University of Crete, Heraklion, Greece
  • S. Charisis
    Dep. of Opthalmology, Institute of Vision, Un Cret, University of Crete, Heraklion, Greece
  • N. Tsiklis
    Dep. of Opthalmology, Institute of Vision, Un Cret, University of Crete, Heraklion, Greece
  • D. Bouzoukis
    Dep. of Opthalmology, Institute of Vision, Un Cret, University of Crete, Heraklion, Greece
  • A. Pallikaris
    Dep. of Opthalmology, Institute of Vision, Un Cret, University of Crete, Heraklion, Greece
  • I. Naoumidi
    Dep. of Opthalmology, Institute of Vision, Un Cret, University of Crete, Heraklion, Greece
  • M. Tsilimbaris
    Dep. of Opthalmology, Institute of Vision, Un Cret, University of Crete, Heraklion, Greece
  • Footnotes
    Commercial Relationships G.D. Kymionis, None; V. Diakonis, None; S. Charisis, None; N. Tsiklis, None; D. Bouzoukis, None; A. Pallikaris, None; I. Naoumidi, None; M. Tsilimbaris, None.
  • Footnotes
    Support None.
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 5328. doi:
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      G. D. Kymionis, V. Diakonis, S. Charisis, N. Tsiklis, D. Bouzoukis, A. Pallikaris, I. Naoumidi, M. Tsilimbaris; Effect of Topical Mitomycin C on Ciliary Body and Intraocular Pressure After Photorefractive Keratectomy: An Experimental Study. Invest. Ophthalmol. Vis. Sci. 2007;48(13):5328.

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Abstract

Purpose:: To investigate the effects of mitomycin C (MMC) on ciliary body and intraocular pressure (IOP) when used after photorefractive keratectomy (PRK) in an experimental model.

Methods:: Forty eyes of 20 rabbits underwent PRK to correct -8 diopters (D) in a 5 mm optical zone. Sterile surgical sponges (5mm) soaked with 0.02% MMC were applied over the corneas exposed stroma randomly on one eye for two minutes (study group), while on the fellow eye (control group), sponges soaked with balanced salt solution (BSS) were applied for the same time. Ciliary bodies were evaluated histologically, in a masked fashion, by light and transmission electron microscopy.

Results:: Histological examination of the morphology of ciliary body structures did not reveal any difference between the examined groups. Furthermore, tonometric measurements of the IOP remained stable during the follow-up period with no significant changes between the interval meantime (p=0.75).

Conclusions:: Adjuvant application of MMC after PRK does not seem to induce alterations on the ciliary body or to changes in IOP measurements.

Keywords: refractive surgery: PRK • ciliary body • drug toxicity/drug effects 
© 2007, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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