Abstract
Purpose::
To analyze the results of prophylactic intraoperative use of mitomycin C (MMC) following photorefractive keratectomy (PRK) in patients previously submitted to penetrating keratoplasty (PKP) and significant anisometropia with no tolerance to contact lenses.
Methods::
retrospective analysis of 23 eyes previously submitted to PKP that received MMC 0.02% intraoperatively (for 30 seconds).
Results::
Mean follow-up was 12 months (range, 9-18). Preoperative spherical equivalent refraction was - 5.24 +/- 3.32 diopters (D) and -1.15 +/- 0.92 postoperatively. Best spectacle-corrected visual acuity was 0.68 +/- 0.12 preoperatively and 0.72 +/- 0.14 postoperatively. Uncorrected visual acuity (UCVA) > or = 20/40 was obtained in 72.3% of cases; UCVA > or = 20/25 was achieved in 36.4% of cases. No corneal haze, side effects or toxic effects were documented during slit-lamp examination. No statistically significant decrease in endothelial cell count was evidenced at 3, 6 and 9 months postoperatively (p < 0.001).
Conclusions::
Prophylactic use of intraoperative MMC following PRK in patients previously submitted to corneal transplant is apparently a safe and effective LASIK alternative for patients with significant anisometropia and contact lenses intolerance.
Keywords: refractive surgery: PRK • refractive surgery: optical quality • cornea: clinical science