May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Cutaneous Nevi and Freckles Are Associated With Uveal Melanoma: A Meta-Analysis
Author Affiliations & Notes
  • C. P. Shah
    Oncology Service, Wills Eye, Philadelphia, Pennsylvania
  • E. Weis
    University of Alberta, Edmonton, Alberta, Canada
  • M. Lajous
    Harvard School of Public Health, Boston, Massachusetts
  • J. A. Shields
    Oncology Service, Wills Eye, Philadelphia, Pennsylvania
  • C. A. Shields
    Oncology Service, Wills Eye, Philadelphia, Pennsylvania
  • Footnotes
    Commercial Relationships C.P. Shah, None; E. Weis, None; M. Lajous, None; J.A. Shields, None; C.A. Shields, None.
  • Footnotes
    Support None.
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 5492. doi:
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      C. P. Shah, E. Weis, M. Lajous, J. A. Shields, C. A. Shields; Cutaneous Nevi and Freckles Are Associated With Uveal Melanoma: A Meta-Analysis. Invest. Ophthalmol. Vis. Sci. 2007;48(13):5492.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose:: To review the literature and conduct a meta-analysis of observational studies examining the relationship between cutaneous nevi and uveal melanoma.

Methods:: The authors extracted risk factor data from 11 observational studies and categorized the data into four a priori groups: 1) atypical cutaneous nevi, 2) common cutaneous nevi, 3) cutaneous freckles, and 4) iris nevi.

Results:: Meta-analysis of four studies (850 cases) examining atypical cutaneous nevi yielded a summary OR of 4.26 (1.44 - 12.57, p=0.009). Common cutaneous nevi was reported in four studies (825 cases), yielding a summary OR of 1.74 (1.27 - 2.39, p=0.001). Cutaneous freckles using 7 studies (2122 cases) found an OR = 1.22 (1.03 - 1.45, p= 0.022). Iris nevi using 4 studies (825 cases) found an OR of 1.53 (1.03 - 2.27, p = 0.036). There was no evidence of publication bias for the aforementioned risk factors, with the exception of atypical cutaneous nevi (p = 0.03).

Conclusions:: This meta-analysis supports an association between uveal melanoma and atypical cutaneous nevi, common cutaneous nevi, cutaneous freckles, and iris nevi. The reported association between uveal melanoma and atypical cutaneous nevi may be overestimated due to publication bias.

Keywords: tumors • uvea • clinical (human) or epidemiologic studies: biostatistics/epidemiology methodology 
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