May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
The Preliminary Results of a Case Control Study Using Infrared Video Pupillographic Techniques to Determine What Effect Tamulosin Has on Physiological Pupil Parameters
Author Affiliations & Notes
  • M. J. Hove
    Ophthalmology, St Thomas Hospital, London, United Kingdom
  • D. J. Spalton
    Ophthalmology, St Thomas Hospital, London, United Kingdom
  • E. Gavin
    Ophthalmology, St Thomas Hospital, London, United Kingdom
  • F. Bremner
    Ophthalmology, National Institute For Neurology and Neurosurgery, London, United Kingdom
  • Footnotes
    Commercial Relationships M.J. Hove, None; D.J. Spalton, None; E. Gavin, None; F. Bremner, None.
  • Footnotes
    Support Guy's and St Thomas Charity
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 5537. doi:
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      M. J. Hove, D. J. Spalton, E. Gavin, F. Bremner; The Preliminary Results of a Case Control Study Using Infrared Video Pupillographic Techniques to Determine What Effect Tamulosin Has on Physiological Pupil Parameters. Invest. Ophthalmol. Vis. Sci. 2007;48(13):5537.

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Abstract
 
Purpose:
 

To report the preliminary results of a case control study todetermine what effect tamulosin has on physiological pupil parameters.

 
Methods:
 

16 patients already taking tamulosin were recruited from a urologyclinic. They were compared to 16 healthy controls who had nevertaken tamulosin. Pupil evaluation was by infra-red pupillographictechniques. Pupil diameters in the light and dark, and thenat 15, 30, 60 and 120 minutes after instillation of 10µlof 10% phenylephrine or 10µl of 10% phenylephrine and10µl of 1% cyclopentolate. The two different preparationswere randomised to each eye. The time for 75% recovery of thepupil size following presentation of a standard light stimulus(T3/4) was calculated.

 
Results:
 

The cohort on tamulosinhad longer T3/4 times, but dilated less in response phenylephrine(due to the alpha-adrenoceptor antagonist effect of tamulosin)as the healthy controls. We then compared the individual T3/4in this cohort to the normal database collected by the Nationalhospital for Neurology and Neurosurgery to see if all the patientson tamulosin had abnormal T3/4 times.Tamulosin cohort (sub-groupanalysis) 

 

 
Conclusions:
 

50% of patients who were on tamulosin had abnormal T3/4 times.These patients had also been on tamulosin for longer indicatingthat the effect of tamulosin on pupillary reactions seems tobe related to duration of use. The patients on tamulosin withnormal T3/4 were similar to the healthy controls. Further workis underway to see if abnormal T3/4 is correlated to the diagnosisof IFIS.

 
Keywords: pupillary reflex • drug toxicity/drug effects 
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