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A. H. Rogers, R. W. Chen, J. S. Duker, C. R. Baumal, E. Reichel, I. Gorczynska, J. J. Liu, V. Srinivasan, J. S. Schuman, J. G. Fujimoto; Enhanced Imaging of Macular Pathologies With the High Speed, Fourier Domain RTVue Optical Coherence Tomography Instrument. Invest. Ophthalmol. Vis. Sci. 2007;48(13):5663.
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To perform a cross-sectional study of retinal pathologies with the RTVue Fourier domain optical coherence tomography system (Optovue, Inc., Fremont, CA). To identify situations where RTVue Optical coherence tomography (OCT) provides improved performance compared to standard OCT systems.
RTVue OCT is capable of 26,000 axial scans / second compared to 400 axial scans / second on standard time domain OCT (Stratus OCT), and ~5 µm axial resolution compared to ~10 µm resolution of standard OCT. The increased speed and resolution allows for high transverse pixel density images, dense raster scans, and three-dimensional (3D) imaging of retinal topography. High resolution RTVue OCT and standard resolution Stratus OCT were performed in the same patients, and results were correlated with standard ophthalmologic clinical exams.
RTVue OCT was performed in >75 patients with a variety of retinal pathologies, including age-related macular degeneration, diabetic retinopathy, macular edema, vitreomacular traction, macular hole, epiretinal membrane, and central serous chorioretinopathy. High resolution images captured more detail of intraretinal structures such as the photoreceptor inner segment/outer segment junction, ganglion cell layer, and retinal pigment epithelium. Pathology such as edema that could not be identified on standard OCT was identified on RTVue OCT. 3D imaging provided surgically relevant topographical and structural information in cases of macular holes and epiretinal membranes.
The RTVue Fourier domain OCT instrument offers significant improvement in visualization of retinal structures compared to standard OCT. High resolution images capture details that may be missed on standard OCT. 3D imaging provides improved coverage and retinal topographical information, and it offers the potential to track pathology from visit to visit.
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