May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Retina 1 Project. Validation of a Predictive Risk Formula for Developing Proliferative Vitreoretinopathy (PVR) in Patients With Retinal Detachment (RD)
Author Affiliations & Notes
  • J. C. Pastor
    Eye Institute-IOBA, University of Valladolid, Valladolid, Spain
    University Hospital, Valladolid, Spain
  • I. Fernández
    Eye Institute-IOBA, University of Valladolid, Valladolid, Spain
  • E. Rodríguez de la Rúa
    Eye Institute-IOBA, University of Valladolid, Valladolid, Spain
    University Hospital, Valladolid, Spain
  • J. M. Ruiz Moreno
    IOA, Alicante, Spain
  • J. Elizalde
    Barraquer Clinic, Barcelona, Spain
  • C. V. Rui Martinho
    San João Hospital, Oporto, Portugal
  • M. Alfaiate
    University Hospital, Coimbra, Portugal
  • M. S. Figueroa
    Ramón y Cajal Hospital, Madrid, Spain
  • S. Velilla
    San Millán Hospital, La Rioja, Spain
  • Retina 1 Project
    Eye Institute-IOBA, University of Valladolid, Valladolid, Spain
  • Footnotes
    Commercial Relationships J.C. Pastor, None; I. Fernández, None; E. Rodríguez de la Rúa, None; J.M. Ruiz Moreno, None; J. Elizalde, None; C.V. Rui Martinho, None; M. Alfaiate, None; M.S. Figueroa, None; S. Velilla, None.
  • Footnotes
    Support Sociedad Española de Oftalmología and FIS-FEDER PI041701 HIGHWIRE EXLINK_ID="48:5:5709:1" VALUE="PI041701" TYPEGUESS="GEN" /HIGHWIRE
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 5709. doi:
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      J. C. Pastor, I. Fernández, E. Rodríguez de la Rúa, J. M. Ruiz Moreno, J. Elizalde, C. V. Rui Martinho, M. Alfaiate, M. S. Figueroa, S. Velilla, Retina 1 Project; Retina 1 Project. Validation of a Predictive Risk Formula for Developing Proliferative Vitreoretinopathy (PVR) in Patients With Retinal Detachment (RD). Invest. Ophthalmol. Vis. Sci. 2007;48(13):5709.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose:: To validate a predictive formula (Pastor JC et al. Curr Eye Res 2005 30:147-153) estimating the risk of development of PVR in patients with RD from new data collected in 13 centers in Spain and Portugal.

Methods:: A multicenter prospective study is going on, collecting 83 pre, intra and postoperative variables (follow up 3 months). For this work data from 546 consecutive patients with RD admitted for surgery has been used to validate a formula previously developed using 335 patients collected from 5 of the participating groups 5 years ago (G0). Five groups have been considered. Global sample (GS), new patients from the 5 centers which defined the formula (G1) and patients from 3 centers with different PVR rates: G2 low (1.69%); G3 medium (8.6%); and G4 high (21%). Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) have been calculated.

Results:: Vitrectomy, more non-visible retinal breaks and re-operations were more frequently found in GS than in G0. PVR incidence (10.8%) in GS was similar to the obtained in G0 (9.9%), but sensitivity [49.2% (CI 95%:36.8%-61.6%)] and specificity [46% (CI 95%:41.6%-50.4%)] were significantly lower than previous published (sensitivity 67%, specificity 81%).In G1 (n: 143) PPV was 12.9% (CI 95%: 5.1%-28.9%) and NPV 94.6% (CI 95%: 88.8%-97.5%).In G2 (n: 60), PPV was 50% (CI 95%: 9.5%-90.5%) and NPV 98.3% (CI 95%: 90.9%-99.7%). In G3 (n: 93) PPV was 66.7% (CI 95%: 30%-90.3%) and NPV 95.4% (CI 95%: 88.8%-98.2%). In G4 (n: 101) PPV was 22.1% (CI 95%: 13.8%-33.3%) and NPV 81.3% (CI 95%: 64.7%-91.1%).

Conclusions:: Predictive formulas for PVR based on clinical risk factors have a limited value because they are greatly influenced by characteristics of RD and its surgical management which have been modified during the last 5 years. This emphasizes the role of large multicenter, prospective studies such as Retina 1, providing an updated information on a regular basis.

Keywords: proliferative vitreoretinopathy • retinal detachment • clinical (human) or epidemiologic studies: risk factor assessment 
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