Abstract
Purpose::
To determine the effect of intensive anti-inflammatory therapy as an adjuvant in the treatment of established proliferative vitreoretinopathy (PVR).
Methods::
A consecutive case series of patients with grade C PVR were enrolled. All patients underwent vitrectomy and silicone oil injection with membrane peeling and retinectomy as required. Treatment consisted of pre-operative topical prednisolone acetate; per-operative intravitreal triamcinolone 4mg and sub-tenon injection of triamcinolone 40mg; post-operative topical prednisolone actetate and oral flurbiprofen 50mg.
Results::
13 patients (7 male and 6 female) were recruited. At least five clock hours of grade C PVR was present in all patients. 7 patients had previous surgery for rhegmatogenous retinal detachment prior to enrolment. In 11 of 13 patients (85%) the retina was successfully attached following surgery. In 1 patient the retina re-detached following removal of silicone oil and 1 patient developed a tractional retinal detachment under silicone oil. A post-operative rise in intraocular pressure was observed in 1 patient and was controlled with topical medication.
Conclusions::
Intensive ant-inflammatory adjunctive therapy is a feasible and well tolerated treatment of established PVR. Further studies are now underway.
Keywords: retinal detachment • proliferative vitreoretinopathy