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C. Thimonier, P. Daubas, L. Bourdon, R. Vignal, V. Deral-Stephant, C. Roux, J.-P. Menu; Effects of Hyperoxia on the Retinal Elctrophysiology Recorded by Multifocal ERG in Healthy Subjects and Combat Swimmers. Invest. Ophthalmol. Vis. Sci. 2007;48(13):5979.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the influence of hyperoxia on the multifocal ERG in naïve healthy subjects and commonly 100% O2 exposed healthy subjects (combat swimmers).
9 combat swimmers and 10 healthy adults volunteered for this study. Multifocal ERG (mfERG) was recorded using Vision Monitor (Métrovision, France) using a 61-hexagon strategy. Three phases were conducted: room air breathing ("Air1", 0 to 40 min), pure oxygen breathing ("O2", 40 to 140 min) and room air breathing again ("Air2", 140 to 170 min). MfERG was recorded on the right eye using a jet contact lens electrode at 0, 10 (Air1), 130 (O2) and 170 (Air2) minutes, and using a gold foil electrode at 10, 30 (Air1), 45, 70, 110 (O2) and 146 (Air2) minutes. Results from the 61 zones were rejected or accepted according to a threshold value. Statistic was therefore performed on coefficient of variation (CV) computed from O2 and Air2 compared to Air1 for valid N1 and P1. CV were analysed with Wilcoxon non-parametric test, significance was set at p < 0.05.
N1 and P1 amplitudes of jet electrode records increased at 130 minutes (after 90 min of pure oxygen breathing) respectively by 4.13% (p = 0.07) and 5.14% (p < 0.05) in healthy subjects and by 8.16% (p < 0.05) and 5.79% (p = 0.11) in combat swimmers. For records using gold foil electrode, no change in N1 and P1 amplitudes was observed. No change was observed on implicit times for both gold foil and jet electrodes.
90 min of 100% O2 breathing lead to an increase in N1 and P1 amplitudes of mfERG signal. This effect was observed with the jet electrode, but not when using the gold foil electrode for which the amplitudes were regularly smaller than with the jet electrode. Furthermore it has been shown that both N1 and P1 amplitude variations were more important for combat swimmers than healthy subjects, especially for N1 amplitude. These results suggested that people commonly exposed to pure oxygen breathing are more sensitive to oxygen. This effect remains to be explained.
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